Medicinal Chemist—RNAi Small Molecule Design

OliX Pharmaceuticals, Inc.; San Diego (CA); On-site; USD 85,000 - 145,000; Full time

Benefits offered by this job

Competitive compensation

Medical, Dental, and Vision insurance

401(k) retirement plan

Stock option grants

Professional growth opportunities

Job summary

A clinical-stage biotechnology company in San Diego is seeking a Scientist I/II in Medicinal Chemistry to lead the design and synthesis of small molecules to support RNAi therapeutic development. Candidates should have a Ph.D. or M.S. with significant industry experience, strong skills in synthetic organic chemistry, and proficiency with various analytical techniques. This role offers a competitive salary and benefits, along with opportunities for professional growth.

Qualifications

• Experience in small-molecule drug design is crucial.
• Strong background in synthetic organic chemistry is required.
• Demonstrated ability to optimize molecules for potency and selectivity.

Responsibilities

• Design and synthesize novel small molecules for RNAi therapeutic development.
• Document research results in SOPs and technical reports.
• Collaborate across multidisciplinary teams.

Skills

Synthetic organic chemistry

Small-molecule drug design

Analytical methods (UHPLC, LC/MS, NMR, UV-Vis)

Communication skills

Teamwork skills

Education

Ph.D. in Medicinal Chemistry or related field

M.S. with 5+ years small-molecule industry experience

Tools

UHPLC

LC/MS

NMR

UV-Vis

Job description

A clinical-stage biotechnology company in San Diego is seeking a Scientist I/II in Medicinal Chemistry to lead the design and synthesis of small molecules to support RNAi therapeutic development. Candidates should have a Ph.D. or M.S. with significant industry experience, strong skills in synthetic organic chemistry, and proficiency with various analytical techniques. This role offers a competitive salary and benefits, along with opportunities for professional growth.