RNA Therapeutics Chemist - Translational Innovator

Mayo Clinic; Jacksonville (FL); Presencial; USD 150.000 - 210.000; Tempo integral

Benefícios oferecidos por esta vaga

Startup package

Excellent benefits

Mayo pension plan (403b)

Resumo da vaga

Mayo Clinic Florida is seeking an RNA therapeutics chemist (PhD) to invent and optimize next-generation RNA medicines. You will design ASOs, siRNAs, mRNAs, and novel chemistries, aiming for potent, stable, and tissue-targeted therapies with translational potential.

The role will integrate chemistry with RNA biology, pharmacology, and disease biology, collaborating across disciplines to translate discoveries from design to preclinical development and toward patient therapies.

Qualificações

• PhD in chemistry or closely related discipline with strong RNA/oligonucleotide chemistry background.
• Significant research experience in RNA or oligonucleotide therapeutics.
• Expertise in ASO, siRNA, mRNA, oligonucleotide chemistry, nucleoside chemistry, RNA modification, conjugation, or RNA delivery.
• Ability to connect chemical structure with biological activity and design experiments linking molecular properties to pharmacology.
• Track record of innovative scientific contributions through publications, patents, or programs and NIH/funding success.
• Interest in cross-disciplinary collaboration across biology, pharmacology, and translational medicine.

Responsabilidades

• Design and optimize RNA therapeutic modalities including ASOs, siRNAs, mRNAs and related chemistries.
• Develop novel chemical modifications and delivery strategies for tissue- and cell-selective targeting.
• Advance RNA therapeutics toward preclinical development and clinical translation.
• Collaborate with biologists, pharmacologists, clinicians, and external partners to establish structure–activity relationships.
• Design rigorous experiments to understand molecular properties and therapeutic performance.

Conhecimentos

RNA therapeutics

Oligonucleotide chemistry

Conjugation chemistry

RNA delivery

In vivo pharmacology

Formação

PhD in chemistry, medicinal chemistry, chemical biology, nucleic acid chemistry, or related

Descrição da vaga

Mayo Clinic Florida is seeking an RNA therapeutics chemist (PhD) to invent and optimize next-generation RNA medicines. You will design ASOs, siRNAs, mRNAs, and novel chemistries, aiming for potent, stable, and tissue-targeted therapies with translational potential.

The role will integrate chemistry with RNA biology, pharmacology, and disease biology, collaborating across disciplines to translate discoveries from design to preclinical development and toward patient therapies.