Manager of Flow Cytometry

BioSpace; San Antonio (TX); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Health insurance

401K

Corporate bonus eligibility

Stock incentives

Job summary

BioSpace is seeking a Manager of Flow Cytometry to lead a small team of 2–4 scientists/technologists, oversee day-to-day lab operations, and collaborate with our Clinical team. You will report to the CSO with matrixed support from the VP of Product Development in a dynamic, multi-disciplinary environment.

The role emphasizes hands-on test development, panel design, instrument maintenance, data analysis with FlowJo/R/Python, and ensuring CLIA/CAP/FDA validation readiness through rigorous

Qualifications

• MS or PhD in biology, immunology, or related field.
• 5 years hands-on flow cytometry experience with multi-color panels; 2+ years in supervision.
• Flow cytometry test development experience and analytical validation.
• Familiarity with CLIA, CAP, GCP or equivalent; method validation best practices.
• Proficiency with FlowJo, FCS Express, R, Python and QA/QC approaches.
• Strong communication and collaboration in a multifunctional team.

Responsibilities

• Lead and supervise 2–4 flow cytometry scientists/technologists; hands-on lab work.
• Oversee day-to-day lab operations: equipment, inventory, safety, compliance.
• Develop and optimize sample processing protocols and panel design.
• Prioritize tasks and timelines with project management.
• Instrument standardization, compensation/unmixing, gating, data review, LIS/LIMS.
• Ensure CLIA/CAP/FDA validation documentation and audit readiness.
• Provide scientific analysis and write internal SOPs for flow cytometry.

Skills

Flow cytometry

Panel design

Data analysis (FlowJo/R/Python)

QA/QC

Supervisory experience

Education

MS or PhD in biology/immunology

Tools

FlowJo

FCS Express

R

Python

Job description

About The Role

The Manager of Flow Cytometry oversees day-to-day flow cytometry test development, optimization and pre-validation/validation activities. This role manages a team of scientists/technologists and partners closely with our Clinical team. The Manager will report to the Chief Science Officer with an indirect reporting relationship to the Vice President of Product Development and work within a dynamic team that includes biologists, chemists, technicians, physicians and senior management to develop novel diagnostic tests.

Benefits include health insurance and 401K as well as eligibility for corporate bonus and stock incentives.

Job title: Manager of Flow Cytometry

Key responsibilities

• Lead, mentor, and supervise a small team (2–4) of flow cytometry scientists/technologists (BS and MS) in flow cytometry test development. The position will also entail hands‑on laboratory work by the Manager.
• Oversee day-to-day laboratory operations, including equipment maintenance and calibration, inventory control and procurement of supplies and reagents, laboratory organization, and safety and compliance activities
• Development and optimization of human sample processing protocols, panel development, instrument scheduling.
• Prioritization of tasks and timeline development with project management.
• Instrument standardization, panel design and optimization, compensation/unmixing, gating strategies, data review workflows, and LIS/LIMS integration for result reporting.
• Compliance with existing written procedures for qualification and use of flow cytometers, including sample records, startup/shutdown procedures, QC checks, and reporting of deviations.
• Understanding of major flow cytometry platforms and instrumentation, their maintenance, and their product support pipelines
• Write and edit internal protocols and SOPs for flow cytometry test methods in conjunction with other team members.
• Provide scientific analysis and oversight for complex novel assays.
• Compliance with internal quality requirements and CLIA/CAP/FDA requirements for validation, including documentation, deviation management, and audit readiness in conjunction with the Clinical team.
• Data analysis using flow cytometry data analysis software and internal machine learning algorithms.
• Written and verbal communication: reporting to management, project teams and externally to the company (scientific meetings, posters, publications).

Required Qualifications (tuned For a Manager)

• MS or PhD in biology, immunology, laboratory science or related field.
• 5 years of hands‑on flow cytometry experience, including multi‑color or spectral panels, with at least 2 years in a supervisory or team‑lead role. Spectral cytometry experience is a plus.
• Flow cytometry test development experience, including optimization, analytical validation (precision, accuracy, reportable range, reference intervals, stability, statistical analysis, etc.). Clinical testing lab experience is a plus.
• Strong expertise in panel design, compensation/spectral unmixing and troubleshooting instrument and staining issues.
• Familiarity with clinical or regulated environments (CLIA, CAP, GCP, or equivalent) and method validation best practices.
• Proficiency with analysis tools (FlowJo/FCS Express/R/Python) and standard gating and QA/QC approaches. Familiarity with statistics, machine learning and code development is a plus.
• Proven ability to communicate orally and in writing and collaborate effectively in a multifunctional team setting with clinical, operations, and business leadership stakeholders.