Scientist, Drug Product Development

NewLimit; South San Francisco (CA); On-site; USD 113,000 - 171,000; Full time

Benefits offered by this job

Health insurance

401(k) plan with company match

Paid parental leave

Industry-leading PTO

On-site meals

Job summary

NewLimit is seeking a Scientist to join our Delivery Sciences team in South San Francisco. You will develop formulations, purification processes, and characterization methods for lipid nanoparticle (LNP) drug products to support reprogramming medicines.

You will collaborate with Epigenetic Editing and Product teams to advance LNP-RNA therapies, optimize LNP compositions for new cell targets, and keep meticulous ELN records. Doctorate-level experience or equivalent industry expertise is expected.

Qualifications

• Ph.D. in Biomedical Engineering, Chemical Biology, Pharmaceutical Sciences, or a related discipline or equivalent industry experience.
• Experience formulating LNPs with diverse lipid components for nucleic acid delivery.
• Experience with purification techniques, including dialysis, Tangential Flow Filtration (TFF), ultracentrifugation, and sterile filtration.
• Proficiency in LNP analysis using dynamic or multi-angle light scattering, liquid chromatography, and standard molecular biology assays (ELISA, qPCR, spectroscopy).

Responsibilities

• Formulate, purify, and characterize LNPs for nucleic acid delivery.
• Collaborate with Epigenetic Editing and Product teams to develop LNP-RNA reprogramming medicines.
• Develop and optimize LNP compositions to target new cell types for reprogramming.
• Interpret complex experimental data and perform statistical analyses to reach robust conclusions.
• Maintain rigorous and detailed records of experimental protocols and results in an ELN.

Skills

LNP formulation

LNP purification

Molecular biology assays

Data analysis

ELN documentation

Education

Ph.D. in Biomedical Engineering

Ph.D. in Chemical Biology

Ph.D. in Pharmaceutical Sciences

Related discipline or equivalent industry experience

Tools

Dynamic light scattering

Multi-angle light scattering

Liquid chromatography

ELISA

qPCR

Spectroscopy

Job description

Company info

NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat aging by reprogramming the epigenome, a new therapeutic mechanism to restore youthful function in aged cells. We’ve built the world’s leading experimental and artificial intelligence system to discover reprogramming medicines at massive scale. Our first products are focused on restoring youthful metabolic, endothelial, and immune function.

Description

NewLimit is seeking a Scientist to join our Delivery Sciences team. In this role, you will development formulations, purification processes, and characterization methods for lipid nanoparticle (LNP) drug products. NewLimit’s reprogramming medicines rely upon these LNP chemistries to carry reprogramming payloads to target cells and tissues throughout the body.

What You’ll Do

• Formulate, purify, and characterize LNPs for nucleic acid delivery
• Collaborate with the Epigenetic Editing and Product teams (Immunology, Metabolism, Vascular) to develop LNP-RNA reprogramming medicines.
• Develop and optimize LNP compositions to target new cell types for reprogramming.
• Interpret complex experimental data and perform statistical analyses to reach robust conclusions.
• Maintain rigorous and detailed records of experimental protocols and results in an Electronic Laboratory Notebook (ELN).

Requirements

• Ph.D. in Biomedical Engineering, Chemical Biology, Pharmaceutical Sciences, or a related discipline or equivalent industry experience
• Experience formulating LNPs with diverse lipid components for nucleic acid delivery
• Experience with purification techniques, including dialysis, Tangential Flow Filtration (TFF), ultracentrifugation, and sterile filtration.
• Proficiency in LNP analysis using dynamic or multi-angle light scatting, liquid chromatography, and standard molecular biology assays (ELISA, qPCR, spectroscopy).

Nice to have

• Experience contributing to drug product development at the preclinical or clinical stages.
• Background in extra-hepatic nucleic acid delivery.
• Experience with bioconjugation, surface modification, or targeted LNP formulation.
• Experience with data visualization and statistical analysis (R, Python)

Benefits

• Comprehensive Health, Dental, and Vision insurance.
• 401(k) plan with company match.
• Paid parental leave.
• Industry-leading PTO**:** 20 days per year plus holidays.
• On-site meals and snacks.

Salary Range: $113,000 to $171,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.