LNP Characterization Advisor — Analytical Development

Lilly; Boston (MA); On-site; USD 141,000 - 207,000; Full time

Benefits offered by this job

Company bonus

401(k) plan

Pension plan

Vacation benefits

Medical/dental/vision benefits

Job summary

Lilly is seeking an Analytical Development Advisor in the United States to advance characterization of lipid nanoparticle formulations within ADS. You will develop and apply biophysical techniques to study nanoparticle morphology, size, and polydispersity at the single-particle level, collaborating across Process Development, Formulation and Bioproduct R&D.

The role emphasizes independent bench work, cross-functional teamwork, and the evaluation of new technologies to enhance structure-function

Qualifications

• PhD with 0–3 years postdoc or industry nanoparticle expertise.
• Hands-on experience with nanoFCM, FFF-MALS, SPARTA, or NTA.
• Strong understanding of nanoparticle biophysics and product performance relationships.

Responsibilities

• Develop and implement biophysical techniques to characterize LNP morphology and size.
• Characterize particle-level features: empty/loaded ratios, ligand density, cargo loading.
• Assess aggregation and stability using single-particle and orthogonal methods.
• Design studies to relate biophysical attributes to product performance.
• Qualify single-particle methods for accuracy, reliability, and reproducibility.
• Collaborate with cross-functional teams to define CQAs related to heterogeneity.
• Analyze complex data sets and present actionable recommendations.
• Identify external collaboration opportunities to deepen understanding.

Skills

Single-particle characterization

Nanoparticle biophysics

Excellent communication

Education

PhD in biophysics, chemistry, or related discipline

Tools

nanoFCM

FFF-MALS

SPARTA

NTA

DLS

cryo-EM

Job description

Lilly is seeking an Analytical Development Advisor in the United States to advance characterization of lipid nanoparticle formulations within ADS. You will develop and apply biophysical techniques to study nanoparticle morphology, size, and polydispersity at the single-particle level, collaborating across Process Development, Formulation and Bioproduct R&D.

The role emphasizes independent bench work, cross-functional teamwork, and the evaluation of new technologies to enhance structure-function