Lipid Nanoparticle Formulation Scientist – RNA Delivery

BioSpace; Redmond (WA); On-site; USD 90,000 - 110,000; Full time

Benefits offered by this job

Free colleague meals during shift

Onsite massages Charis

Onsite gyms

Job summary

GenScript USA Inc/ProBio Inc. in Redmond, WA is seeking a Nanoparticle Formulation Scientist to advance lipid nanoparticle formulations for RNA delivery, focusing on mRNA, DNA, and related therapeutics.

You will develop methods, characterize particles, support production scale-up, and collaborate with IP and customers, writing protocols and reports, while maintaining a clean lab and working with a diverse team.

Qualifications

• Master or PhD in pharmaceutical science, chemistry, biochemistry, chemical engineering or related field, Master is preferred.
• Strong knowledge of lipid and polymeric nanoparticle delivery technologies
• >4 years of relevant experience in nucleic acid delivery with hands-on experience in lipid nanoparticle formulation and characterization
• Extensive experience with production and analytical characterization of nanoparticles
• Proficiency in all molecular biology techniques for mRNA and protein expression (RT-PCR, ELISA, Western blot, Flow-cytometry, etc) and RNA-related analytics (ribogreen, gel electrophoresis, capillary electrophoresis, etc).
• Works collaboratively with team members to support each other
• Excellent communication and problem-solving skills
• A sense of humility and an eagerness to continue to learn and contribute to a supportive team

Responsibilities

• Develop new lipid nanoparticle formulations (lipid or other polymers) platform for mRNA, DNA, RNA, peptide delivery, to achieve targeted delivery for different disease needs
• Develop method for characterizing and evaluating physical characteristics for antibody decorated LNPs
• Process development for high throughput LNP preparation and downstream process to improve production efficiency
• Produce formulations for related RNA projects, supporting functional assays for in vitro evaluation
• Maintain relationships with customers, participate in scientific meetings or customer meetings
• Write study protocols, technical reports, and SOPs to support mRNA product development projects
• Interact with IP counsel to assist with patent prosecution
• Monitors supply inventory and identifies any products required
• Maintains work area, equipment, department and all storage areas in a clean, neat and orderly manner
• Perform other duties as needed

Skills

Lipid nanoparticle delivery

Molecular biology techniques

Team collaboration

Excellent communication

Education

Master/PhD in pharmaceutical science/chemistry/biochemistry/chemical engineering

Job description

GenScript USA Inc/ProBio Inc. in Redmond, WA is seeking a Nanoparticle Formulation Scientist to advance lipid nanoparticle formulations for RNA delivery, focusing on mRNA, DNA, and related therapeutics.

You will develop methods, characterize particles, support production scale-up, and collaborate with IP and customers, writing protocols and reports, while maintaining a clean lab and working with a diverse team.