Lead Upstream Scientist, AAV Process Development

Forge Biologics; Columbus (OH); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

Health insurance

Paid time off

Parental leave

401(k) with company match

Onsite fitness facility

Job summary

Forge Biologics seeks a Scientist II to lead upstream process development for AAV manufacturing. You will design experiments, drive scale-up, and help transfer tech while coordinating with Manufacturing and Quality. Mentor junior scientists and contribute to regulatory support.

The role emphasizes cross-functional collaboration, rigorous data analysis, and hands-on leadership in a cGMP lab at The Hearth in Columbus, OH. You’ll grow with our mission to deliver gene therapies.

Qualifications

• Bachelor’s degree in Chemical Engineering, Bioengineering, Biology, or related discipline (or equivalent).
• Hands-on cell culture with mammalian cells and bioreactor operation.
• Ability to plan and review experiments with minimal oversight.
• Experience training and developing other team members.
• Data analysis to inform decisions and external collaborations.

Responsibilities

• Lead upstream process development for early- to late-stage programs including scale-up and tech transfer.
• Design complex DoE studies, write reports, and contribute to GMP documentation.
• Mentor junior scientists and guide experimental design and data records.
• Coordinate with Process Development, Manufacturing, and Quality for alignment.
• Identify challenges and develop solutions to ensure technical success.

Skills

Upstream process development

Cell culture techniques

Bioreactor operation

Experimental design

Data interpretation

Cross-functional collaboration

Mentoring junior scientists

Education

Bachelor’s in Chemical Engineering

Bachelor’s in Bioengineering

Bachelor’s in Biology

Related discipline or experience

Master’s or PhD (preferred)

Tools

Bioreactors

Job description

Forge Biologics seeks a Scientist II to lead upstream process development for AAV manufacturing. You will design experiments, drive scale-up, and help transfer tech while coordinating with Manufacturing and Quality. Mentor junior scientists and contribute to regulatory support.

The role emphasizes cross-functional collaboration, rigorous data analysis, and hands-on leadership in a cGMP lab at The Hearth in Columbus, OH. You’ll grow with our mission to deliver gene therapies.