Lead In Vivo Genome Engineering Scientist

St. Jude; Lauderdale Courts (TN); On-site; USD 60,000 - 105,000; Full time

Job summary

St. Jude in Tennessee is seeking a Lead or Senior In Vivo Researcher to direct the in vivo translational pipeline for genome engineering therapies targeting hemoglobinopathies and pediatric diseases.

You will manage humanized models, oversee precise delivery of therapeutics, and champion welfare through 3Rs, ensuring compliance with ILAR and USDA guidelines. The role requires expertise in hematopoietic stem cells, MACS, flow cytometry, and advanced in vivo methods, with mentoring

Qualifications

• Bachelor's degree in a relevant scientific area.
• Master's degree or higher strongly preferred.
• Experience with hematopoietic stem cells (HSCs) handling and genome engineering is valued.

Responsibilities

• Lead and execute in vivo studies using humanized and disease models to evaluate genome engineering outcomes.
• Isolate and characterize HSCs and targeted populations using MACS and flow cytometry.
• Engraft, maintain and study humanized models to support translational research.
• Deliver in vivo therapies using minimally invasive delivery methods while maintaining welfare standards.
• Perform aseptic sampling, dosing, and downstream molecular analyses per study design.

Skills

In vivo research

Animal welfare compliance

Education

Bachelor's degree in a relevant scientific area

Master's degree or higher

Tools

Flow cytometry

MACS

Job description

St. Jude in Tennessee is seeking a Lead or Senior In Vivo Researcher to direct the in vivo translational pipeline for genome engineering therapies targeting hemoglobinopathies and pediatric diseases.

You will manage humanized models, oversee precise delivery of therapeutics, and champion welfare through 3Rs, ensuring compliance with ILAR and USDA guidelines. The role requires expertise in hematopoietic stem cells, MACS, flow cytometry, and advanced in vivo methods, with mentoring