Lead Researcher: Leukemia Biology & Translational Science

St. Jude; Lauderdale Courts (TN); Presencial; USD 90.000 - 130.000; Jornada completa

Descripción de la vacante

St. Jude Children's Research Hospital in Memphis, TN seeks a motivated Lead Researcher to investigate the biologic basis of fusion oncoprotein-driven ALL.

The role leads in vitro and in vivo leukemia modeling, coordinating molecular biology, cell culture, and translational science. You will work with multidisciplinary teams to nominate therapeutic targets and translate findings into improved therapies for childhood leukemia; hands-on experience in genomics, cancer models, and functional assays

Formación

• Bachelor's degree in a relevant scientific area is required.
• 5+ years of research experience is required; 3+ years with a Master's degree; PhD not required.

Responsabilidades

• Perform molecular and cell biology experiments to investigate the molecular mechanisms underlying fusion oncoprotein-driven ALL
• Conduct molecular biology techniques, including DNA/RNA isolation, PCR-based assays, and Western blotting
• Perform flow cytometry and functional assays to evaluate cellular phenotypes, signaling pathways, and therapeutic responses
• Contribute to fusion oncoprotein-driven leukemia modeling using in vitro and in vivo experimental approaches
• Apply proteomics, structural biology, and functional genomics approaches to identify and characterize potential therapeutic targets
• Analyze, interpret, and document experimental data
• Collaborate with multidisciplinary research teams, and contribute to the development of improved therapies for children with leukemia

Conocimientos

Molecular biology

Cell culture

Flow cytometry

PCR

Western blotting

In vivo models

Proteomics

Structural biology

Functional genomics

DNA/RNA isolation

Educación

Bachelor's degree in a relevant scientific area

Herramientas

Xenograft modeling

Descripción del empleo

St. Jude Children's Research Hospital in Memphis, TN seeks a motivated Lead Researcher to investigate the biologic basis of fusion oncoprotein-driven ALL.

The role leads in vitro and in vivo leukemia modeling, coordinating molecular biology, cell culture, and translational science. You will work with multidisciplinary teams to nominate therapeutic targets and translate findings into improved therapies for childhood leukemia; hands-on experience in genomics, cancer models, and functional assays