Lead Researcher - Fusion-Driven Leukemia & Translational Science

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 90,000 - 130,000; Full time

Job summary

St. Jude Children's Research Hospital, Inc. seeks a Lead Researcher to investigate the biological basis of fusion oncoprotein-driven ALL, integrating leukemia biology, molecular biology, structural biology, functional genomics, and translational science.

The role leads in vitro and in vivo leukemia modeling, including cell culture, flow cytometry, DNA/RNA isolation, Western blotting, and functional assays, with a focus on translating findings into improved therapies for affected children.

Qualifications

• Bachelor’s degree in a relevant scientific field required; 5+ years research experience; with a Master’s degree, 3+ years; PhD may waive some requirements.

Responsibilities

• Perform molecular and cell biology experiments to investigate molecular mechanisms of fusion oncoprotein-driven ALL
• Conduct DNA/RNA isolation, PCR-based assays, and Western blotting
• Perform flow cytometry and functional assays to evaluate cellular phenotypes and therapeutic responses
• Contribute to fusion oncoprotein-driven leukemia modeling using in vitro and in vivo approaches
• Apply proteomics, structural biology, and functional genomics to identify therapeutic targets
• Analyze, interpret, and document experimental data
• Collaborate with multidisciplinary teams to develop improved therapies for children with leukemia

Skills

Molecular biology

Cell culture

Flow cytometry

DNA/RNA isolation

Western blot

Functional assays

Genomics

Cancer models

In vivo studies

Education

Bachelor’s degree in science

Master’s degree

PhD

Job description

St. Jude Children's Research Hospital, Inc. seeks a Lead Researcher to investigate the biological basis of fusion oncoprotein-driven ALL, integrating leukemia biology, molecular biology, structural biology, functional genomics, and translational science.

The role leads in vitro and in vivo leukemia modeling, including cell culture, flow cytometry, DNA/RNA isolation, Western blotting, and functional assays, with a focus on translating findings into improved therapies for affected children.