Lead Researcher - Experimental Leukemia Modeling, Mullighan Lab

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 90,000 - 130,000; Full time

Job summary

St. Jude Children's Research Hospital, Inc. seeks a Lead Researcher to investigate the biological basis of fusion oncoprotein-driven ALL, integrating leukemia biology, molecular biology, structural biology, functional genomics, and translational science.

The role leads in vitro and in vivo leukemia modeling, including cell culture, flow cytometry, DNA/RNA isolation, Western blotting, and functional assays, with a focus on translating findings into improved therapies for affected children.

Qualifications

• Bachelor’s degree in a relevant scientific field required; 5+ years research experience; with a Master’s degree, 3+ years; PhD may waive some requirements.

Responsibilities

• Perform molecular and cell biology experiments to investigate molecular mechanisms of fusion oncoprotein-driven ALL
• Conduct DNA/RNA isolation, PCR-based assays, and Western blotting
• Perform flow cytometry and functional assays to evaluate cellular phenotypes and therapeutic responses
• Contribute to fusion oncoprotein-driven leukemia modeling using in vitro and in vivo approaches
• Apply proteomics, structural biology, and functional genomics to identify therapeutic targets
• Analyze, interpret, and document experimental data
• Collaborate with multidisciplinary teams to develop improved therapies for children with leukemia

Skills

Molecular biology

Cell culture

Flow cytometry

DNA/RNA isolation

Western blot

Functional assays

Genomics

Cancer models

In vivo studies

Education

Bachelor’s degree in science

Master’s degree

PhD

Job description

We are seeking a motivated and detail-oriented Lead Researcher to investigate the biologic basis of fusion oncoprotein-driven acute lymphoblastic leukemia (ALL). This is a highly collaborative research project that integrates leukemia biology, molecular biology, structural biology, functional genomics, and translational science. The successful candidate will lead and support in vitro and in vivo leukemia modeling, including molecular biology, mammalian cell culture and in vivo xenograft and engineered leukemia modeling, proteomics, structural biology and functional genomics. The project will characterize the sequence determinants of biomolecular condensate formation and hematopoietic transformation, with the ultimate goal of nominating and translating therapeutic approaches. The project part of a NCI project grant involving investigators with expertise in structural biology, brain tumor modeling, epigenomics and functional genomics. The ideal candidate will have hands‑on experience in molecular and cell biology, including cell culture, flow cytometry, DNA/RNA isolation, western blotting and functional assays. Experience with genomics, cancer models, or in vivo studies is highly desirable. This position offers an exciting opportunity to contribute to fundamental and translational research aimed at developing improved therapies for children with leukemia.

Job Responsibilities

• Perform molecular and cell biology experiments to investigate the molecular mechanisms underlying fusion oncoprotein-driven ALL
• Conduct molecular biology techniques, including DNA/RNA isolation, PCR-based assays, and Western blotting
• Perform flow cytometry and functional assays to evaluate cellular phenotypes, signaling pathways, and therapeutic responses
• Contribute to fusion oncoprotein-driven leukemia modeling using in vitro and in vivo experimental approaches
• Apply proteomics, structural biology, and functional genomics approaches to identify and characterize potential therapeutic targets
• Analyze, interpret, and document experimental data
• Collaborate with multidisciplinary research teams, and contribute to the development of improved therapies for children with leukemia

Minimum Education and/or Training

Minimum Education and/or Training: Bachelor’s degree in a relevant scientific area is required Minimum Experience: 5+ years of research experience is required. 3+ years of experience is required with a Master’s degree No prior experience required with a PHD Strong knowledge and experience in understanding and application of underlying principles related to techniques being performed Experience in R&D methods and processes in lab setting, and execution of research projects for the laboratory preferred Proven performance in earlier role/comparable role

We are committed to a human-centered hiring experience. Technology may support portions of our process, but recruiting decisions involve human review and engagement. Learn more about our approach to AI. St. Jude is an Equal Opportunity Employer