Lead, Quantitative Pharmacology & Pharmacometrics - CardioMetabolic

Scorpion Therapeutics; South San Francisco (CA); On-site; USD 160,000 - 240,000; Full time

Job summary

Scorpion Therapeutics in South San Francisco, CA seeks a senior leader in pharmacometrics to drive model-based decision making across translational PK/PD, QSP, and regulatory strategy. You will develop and apply quantitative frameworks and collaborate with discovery, development, and regulatory teams.

Lead cross-disciplinary modeling efforts, mentor junior scientists, and partner with external vendors to ensure rigorous, model-informed go/no-go decisions throughout drug development.

Qualifications

• Ph.D. (4+ years), PharmD (6+ years), or MS (8+ years) in increasing-responsibility roles in drug development, regulatory, or academia.
• Background in biopharmaceutics/pharmaceutical sciences/pharmacometics or related quantitative discipline.
• Experience performing population PK and PK/PD analyses using R, Matlab, Phoenix, NONMEM, Monolix, or similar tools.
• Strong written/verbal communication and ability to collaborate across disciplines and scope complex problems.
• Knowledge of modeling complex therapeutics, mechanistic modeling/QSP.

Responsibilities

• Develop and apply model-based strategies (translational PK/PD, mechanistic models, population PK/PD, clinical trial simulations) to support quantitative decision-making (dose selection, clinical trial design, go/no-go).
• Represent QP2 on cardiometabolic discovery, early clinical development, and late clinical development teams using quantitative approaches.
• Partner with functional colleagues, external vendors, and strategic partners to build aligned, model-informed approaches supporting discovery, development, and regulatory decisions.
• Collaborate across disciplines on study design, protocol development, execution, data interpretation, reporting, and communication.
• Maintain understanding of global regulatory expectations and contribute to regulatory documents/submissions.
• Provide scientific input to pharmacometrics colleagues on modeling strategy, analyses, interpretation, and reporting.

Skills

Population PK/PKPD analyses

Cross-disciplinary collaboration

Communications

Quantitative modeling

Education

Ph.D. in quantitative drug development

PharmD

MS in related field

Tools

R

MATLAB

Phoenix

NONMEM

Monolix

Job description

Scorpion Therapeutics in South San Francisco, CA seeks a senior leader in pharmacometrics to drive model-based decision making across translational PK/PD, QSP, and regulatory strategy. You will develop and apply quantitative frameworks and collaborate with discovery, development, and regulatory teams.

Lead cross-disciplinary modeling efforts, mentor junior scientists, and partner with external vendors to ensure rigorous, model-informed go/no-go decisions throughout drug development.