Lead, Pooled Screening Core for CAR-T & Cell Therapies

Johnson & Johnson Innovative Medicine; North Carolina; On-site; USD 150,000 - 190,000; Full time

Job summary

Johnson & Johnson is seeking a Sr. Manager, Pooled Screening Core - CAR Screening & Lead Selection in Spring House, PA to lead a centralized pooled screening core within Cell & Genetic Medicines. You will manage scientific strategy, personnel, and cross-functional partnerships to accelerate design-to-lead decisions.

The role requires a Ph.D. in a relevant field, deep expertise in pooled screening, and a proven track record building scalable workflows and leading diverse teams in a fast-paced

Qualifications

• Ph.D. in molecular biology, cell biology, immunology, bioengineering, biotechnology, or related field; substantial industry experience.
• Deep expertise in pooled screening technologies and ability to design, execute, troubleshoot, and interpret complex screening studies.
• Experience leading scientific or multidisciplinary technical teams; mentoring and service-oriented culture.
• Proven ability to build scalable workflows, manage concurrent priorities, ensure quality and delivery.
• Strong cross-functional leadership and relationship-building to influence strategy.

Responsibilities

• Serve as CGM’s scientific lead for pooled screening technologies, strategy, applications, and limitations.
• Develop scalable pooled screening workflows spanning library design, cloning, quality control, cell engineering, functional assays, sequencing readouts, and data interpretation.
• Build trusted relationships with project teams and translate scientific questions into rigorous study designs, controls, models, endpoints, and follow-up plans.
• Lead the Core’s operating model, including project intake, prioritization, resource planning, scheduling, execution, and data delivery, with transparent decision-making and clear communication.
• Ensure high standards for scientific rigor, reproducibility, quality, documentation, sample tracking, biosafety, and knowledge management.
• Monitor Core performance through metrics and drive continuous improvement.
• Provide hands-on scientific and operational oversight, troubleshoot complex studies, and balance priorities.
• Lead and expand the Core team through mentoring and fostering a collaborative culture.
• Represent the Core in portfolio discussions and communicate capacity, priorities, risks, and investment needs.

Skills

Pooled screening

Leadership

Cross-functional collaboration

Scientific strategy

Project management

Communication

Education

PhD in molecular biology

Related discipline acceptable

Tools

Pooled screening tech

Automated HT workflows

Sequencing data analysis

Job description

Johnson & Johnson is seeking a Sr. Manager, Pooled Screening Core - CAR Screening & Lead Selection in Spring House, PA to lead a centralized pooled screening core within Cell & Genetic Medicines. You will manage scientific strategy, personnel, and cross-functional partnerships to accelerate design-to-lead decisions.

The role requires a Ph.D. in a relevant field, deep expertise in pooled screening, and a proven track record building scalable workflows and leading diverse teams in a fast-paced