Lead, Movement Disorders Clinical Development

Praxis Precision Medicines, Inc.; Boston (MA); On-site; USD 280,000 - 350,000; Full time

Job summary

Praxis Precision Medicines, Inc. is seeking a hands-on clinical leader to own development decisions across movement disorders, including essential tremor and new indications.

You will shape strategy, lead studies from design through execution, and interpret emerging data. This role requires owning regulatory submissions, health authority interactions, and cross-functional coordination to move programs forward.

Qualifications

• Advanced scientific degree (MD, PharmD, PhD or equivalent) required.
• Track record of personally leading clinical trials or development decisions.
• Regulatory submissions ownership having carried the clinical content of IND, CTA, NDA, or MAA filings, briefing books, and health authority interactions.
• Strong judgment and the ability to make timely calls on emerging data with incomplete information and the knowledge of what to elevate and when.
• Comfort operating in a dynamic environment within a small, flexible organization where scope shifts and the role is defined by what needs doing rather than by a job description.
• You’ll thrive here if you take ownership, challenge assumptions with scientific rigor, move with urgency without sacrificing quality, and stay focused on outcomes that matter for patients.

Responsibilities

• Movement disorders development: Deep understanding of the disease area, endpoints, rating instruments, and patient experience, to development strategy and decision‑making.
• Clinical strategy and trials: Translate science, emerging data, patient need, and regulatory requirements into development strategies—and personally lead studies from design through execution.
• Data‑driven decisions: Interpret emerging clinical and scientific data, identify what matters, and make timely calls when information is incomplete.
• Regulatory strategy: Own substantive clinical content for regulatory filings, briefing materials, and health authority interactions.
• Cross‑functional leadership: Drive teams across clinical operations, biostatistics, regulatory, safety, and other disciplines to resolve issues and move programs forward.
• External leadership: Represent Praxis credibly with investigators, KOLs, health authorities, and partners.

Skills

Clinical leadership

Regulatory strategy

Cross-functional leadership

Data interpretation

Decision making under uncertainty

Ownership & accountability

Education

MD/PhD/PharmD or equivalent

Job description

Praxis Precision Medicines, Inc. is seeking a hands-on clinical leader to own development decisions across movement disorders, including essential tremor and new indications.

You will shape strategy, lead studies from design through execution, and interpret emerging data. This role requires owning regulatory submissions, health authority interactions, and cross-functional coordination to move programs forward.