Lead Mass Spectrometry Scientist - Bioanalysis & Proteins

Biohaven; Cambridge (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Biohaven seeks an experienced Mass Spectrometry Scientist/Sr. Scientist to elevate the Mass Spectrometry group in Cambridge, MA.

This contract‑to‑hire role focuses on targeted protein degradation and next‑generation biologics, shaping bioanalytical strategy for discovery programs. The candidate will lead LC‑MS/MS and IP assay development, peptide mapping, PTM, and glycosylation analyses, while expanding instrumentation and workflows.

Qualifications

• Minimum of 5 years of experience in mass spectrometry-based bioanalytical sciences.
• Experience with mass spectrometry analysis of proteins and peptides on Sciex QTRAP, Sciex Q-TOF, Thermo Orbitrap Fusion/Lumos, QQQ with MRM.
• Demonstrated expertise leading bioanalytical method development and validation of large molecule analytes.
• Experience performing intact and subunit protein mass spectrometry analysis, including characterization of monoclonal antibodies and fusion proteins.
• Hands‑on experience with chromatography techniques (RP-HPLC, SEC, HILIC, nanoLC, microLC).
• Proficient in wet lab sample preparation techniques (SPE, IP, LLE).
• Ability to own and troubleshoot mass spectrometry instrumentation in collaboration with vendors.

Responsibilities

• Drive development, optimization, and validation of LC‑MS/MS and IP assays for quantification of biomarkers, proteins, peptides, cytokines, and metabolites.
• Architect and lead workflows for peptide mapping, PTM analysis, disulfide mapping, and glycosylation analysis.
• Develop novel, fit‑for‑purpose bioanalytical methods for complex proteins.
• Set goals and priorities for bioanalysis across cross‑functional project teams.
• Lead advanced data processing and statistical analysis across vendor software platforms.
• Own the performance of key analytical instrumentation and expand capabilities with vendors.
• Author technical reports, SOPs, and electronic notebook records to document group knowledge.
• Mentor junior scientists and provide scientific leadership to the Mass Spectrometry group.

Skills

MS-based bioanalysis

Protein/peptide MS

Instrumentation troubleshooting

Method development & validation

Chromatography (RP-HPLC, SEC, HILIC)

SPE/IP/LLE sample prep

Cross-functional collaboration

Scientific leadership

Tools

Sciex QTRAP

Sciex Q-TOF

Thermo Orbitrap Fusion/Lumos

QQQ with MRM

Job description

Biohaven seeks an experienced Mass Spectrometry Scientist/Sr. Scientist to elevate the Mass Spectrometry group in Cambridge, MA.

This contract‑to‑hire role focuses on targeted protein degradation and next‑generation biologics, shaping bioanalytical strategy for discovery programs. The candidate will lead LC‑MS/MS and IP assay development, peptide mapping, PTM, and glycosylation analyses, while expanding instrumentation and workflows.