Lead Electrochemical DNA Synthesis & Microarray Scientist

AtlasBase; South San Francisco (CA); On-site; USD 150,000 - 230,000; Full time

Job summary

AtlasBase seeks a highly skilled scientist to advance CMOS chip-based phosphoramidite DNA synthesis workflows and electrochemical DNA synthesis protocols at our South San Francisco labs.

You will collaborate across R&D and manufacturing to build prototype testbeds, optimize synthesis fidelity, and leverage NGS analytics for quality assessment of oligonucleotide pools. Strong problem-solving and cross-functional communication are essential for success.

Qualifications

• Advanced degree in Chemistry/related field.
• 2+ years biotech/pharma R&D for Doctoral degree; 5+ years for Master’s degree.
• Proven track record in phosphoramidite oligonucleotide synthesis chemistry and platform development.
• Experience in oligonucleotide microarray or pool synthesis desirable.
• Hands-on experience with NGS workflows and data analysis desirable.
• Strong understanding of DNA chip technologies and electrochemistry desirable.
• Able to work on cross-functional projects with R&D and manufacturing teams.
• Excellent problem-solving, communication, and project management skills.

Responsibilities

• Develop and optimize CMOS chip-based phosphoramidite DNA synthesis workflows.
• Develop and optimize electrochemical DNA synthesis protocols including chip handling, hardware configuration and software integration.
• Execute rigorous failure-mode analysis across hardware, fluidics, surface chemistry, phosphoramidite chemistry, and electrochemistry.
• Collaborate with engineering and synthesis teams to build prototype testbeds integrating chemistry, fluidics and hardware.
• Operate NGS-based analytical pipelines for quality assessment of oligonucleotide pools.
• Analyze experimental data using molecular biology and organic chemistry techniques.
• Drive technology transfers from R&D to manufacturing with scale-up documentation.
• Define and execute scientific objectives aligned with company goals.
• Present experimental plans, results, conclusions, and next steps at meetings.
• Maintain detailed records of all experimental work and analysis.

Skills

PhD or MSc in Chemistry/related

Biotech R&D experience

Phosphoramidite oligonucleotide synth

Oligonucleotide microarray/pool synth

NGS workflows & data analysis

DNA chip technologies

Electrochemistry knowledge

Cross-functional collaboration

Problem solving

Project management

Education

PhD or Master’s in Chemistry/related field

Tools

NGS instruments

Electrochemistry hardware setup

Job description

AtlasBase seeks a highly skilled scientist to advance CMOS chip-based phosphoramidite DNA synthesis workflows and electrochemical DNA synthesis protocols at our South San Francisco labs.

You will collaborate across R&D and manufacturing to build prototype testbeds, optimize synthesis fidelity, and leverage NGS analytics for quality assessment of oligonucleotide pools. Strong problem-solving and cross-functional communication are essential for success.