Lead Clinical Pharmacology Scientist: Modeling & Simulation

Amgen; Thousand Oaks (CA); On-site; USD 190,000 - 260,000; Full time

Benefits offered by this job

Stock-based incentives

Flexible work model

Total Rewards Plan

Retirement plan

Job summary

Amgen is seeking a Principal Scientist in Clinical Pharmacology Modeling and Simulation in Thousand Oaks, CA. You will develop and execute integrated clinical pharmacology and model-informed drug development strategies to inform dose and regimen, study design, and regulatory filings.

You will collaborate with clinical development, biostatistics, regulatory, and other teams to translate data into clear, actionable decisions.

Qualifications

• Doctorate or professional degree with relevant pharmacology focus.
• Experience leading clinical pharmacology strategies across drug development.
• Strong collaboration with multidisciplinary teams and regulatory inputs.

Responsibilities

• Lead clinical pharmacology strategy for FIH dosing and escalation decisions.
• Design and oversee integrated PK/PD plans, DDI, BA/BE, and special-population studies.
• Plan timing for clinical pharmacology components in development programs.
• Contribute to regulatory submissions and health-authority interactions.
• Communicate quantitative analysis results to inform program decisions.

Skills

Clinical Pharmacology Expertise

Leadership

Cross-functional Collaboration

Communication Skills

Education

PhD

PharmD

MD with 2+ years experience

Masters with 5 years experience

Job description

Amgen is seeking a Principal Scientist in Clinical Pharmacology Modeling and Simulation in Thousand Oaks, CA. You will develop and execute integrated clinical pharmacology and model-informed drug development strategies to inform dose and regimen, study design, and regulatory filings.

You will collaborate with clinical development, biostatistics, regulatory, and other teams to translate data into clear, actionable decisions.