Lead Bioanalytical Scientist, PK/PD & Receptor Engagement

Xaira; South San Francisco (CA); On-site; USD 110,000 - 138,000; Full time

Job summary

Xaira Therapeutics is seeking a Principal Associate Scientist to join the Bioanalytical Sciences team. The role focuses on developing and executing ligand binding assays to support PK, PD, and target engagement studies across discovery and translational programs.

The ideal candidate has extensive hands-on experience with ELISA and MSD/ECL, flow cytometry-based assays, and PK/PD analysis in NHP/rodent models. Join a fast-paced, collaborative biotech startup in CA."

Qualifications

• 7+ years of relevant industry experience in bioanalytical sciences.
• Hands-on experience with ligand binding assay platforms (ELISA, MSD/ECL).
• Experience executing flow cytometry-based assays for receptor occupancy or target engagement.
• Experience supporting PK/PD analysis across NHP/rodent species in discovery or translational research.
• Ability to independently execute experiments and troubleshoot technical issues.
• Strong data summarization and presentation skills.
• Excellent attention to detail and rigorous record-keeping.
• Ability to collaborate effectively in a fast-paced team.

Responsibilities

• Develop, optimize, and execute ligand binding assays (ELISA, MSD/ECL) and flow cytometry methods for PK/PD studies in biologic programs.
• Support assay development, qualification, and validation for non-GLP, IND-enabled GLP, and clinical studies.
• Contribute to DMPK and bioanalytical studies to generate PK/PD data for candidate selection.
• Support bioanalytical method development and validation across discovery to clinical programs.
• Process and analyze samples from NHP and rodent matrices.
• Generate and document experimental data to support team decisions.
• Prepare data summaries and presentations for internal program groups and CROs.
• Maintain accurate lab records and ensure reproducibility.
• Collaborate with cross-functional teams on ongoing research programs.

Skills

Ligand binding assays

ELISA

MSD/ECL

Flow cytometry

PK/PD analysis

Data analysis

Laboratory troubleshooting

Documentation

Education

B.S./M.S. in Biochemistry/Immunology/Analytical Chemistry

Job description

Xaira Therapeutics is seeking a Principal Associate Scientist to join the Bioanalytical Sciences team. The role focuses on developing and executing ligand binding assays to support PK, PD, and target engagement studies across discovery and translational programs.

The ideal candidate has extensive hands-on experience with ELISA and MSD/ECL, flow cytometry-based assays, and PK/PD analysis in NHP/rodent models. Join a fast-paced, collaborative biotech startup in CA."