Senior Bioanalytical Scientist, PK/PD & Ligand Binding

Xairatherapeutics; South San Francisco (CA); On-site; USD 110,000 - 138,000; Full time

Job summary

Xaira Therapeutics seeks a Principal Associate Scientist to join the Bioanalytical Sciences team. This lab-based role focuses on developing and executing ligand binding assays (ELISA, MSD/ECL) and flow cytometry to support PK, PD, receptor occupancy, and target engagement studies across discovery programs.

The successful candidate will have 7+ years of industry experience in bioanalytical assay development, possess strong data generation and documentation skills, and collaborate across biology,

Qualifications

• Bachelor's or master's degree in Biochemistry, Immunology, Analytical Chemistry or related field with 7+ years of industry experience.
• Strong hands-on experience with ligand binding assay platforms (ELISA, MSD/ECL).
• Proven experience executing flow cytometry-based assays, ideally for receptor occupancy or target engagement.
• Experience supporting PK/PD sample analysis across NHP and/or rodent species in a discovery or translational research setting.
• Ability to independently execute experiments and troubleshoot technical issues.
• Past experience with summarizing data and presenting to internal or external groups.
• Strong attention to detail, organization, and record keeping.
• Ability to work effectively in a fast-paced, team-oriented environment.

Responsibilities

• Develop, optimize, and execute ligand binding assays (ELISA, MSD/ECL) and flow cytometry-based methods to support PK, PD, receptor occupancy, and target engagement studies for biologic programs
• Support assay development, optimization, qualification, and validation activities for both non-GLP, IND-enabling GLP, and clinical studies
• Contribute to the design and execution of DMPK and bioanalytical studies, generating PK/PD and exposure data to support candidate selection
• Support bioanalytical method development, qualification, and validation for discovery, translational, and clinical programs
• Process and analyze samples across NHP and rodent matrices, including serum, plasma, and tissue
• Generate, analyze, and clearly document experimental data to support team decision-making
• Prepare presentations and data summaries to communicate experimental findings with internal program groups and external CROs.
• Maintain accurate lab records and ensure reproducibility of experimental workflows
• Collaborate with cross-functional teams to support ongoing research programs

Skills

Ligand binding assays

Flow cytometry

PK/PD analysis

Data presentation

Team collaboration

Attention to detail

Education

B.S. or M.S. in Biochemistry, Immunology, Analytical Chemistry, or related field

Job description

Xaira Therapeutics seeks a Principal Associate Scientist to join the Bioanalytical Sciences team. This lab-based role focuses on developing and executing ligand binding assays (ELISA, MSD/ECL) and flow cytometry to support PK, PD, receptor occupancy, and target engagement studies across discovery programs.

The successful candidate will have 7+ years of industry experience in bioanalytical assay development, possess strong data generation and documentation skills, and collaborate across biology,