Lead Bioanalytical LC-MS/MS Scientist (PK & Biomarkers)

Eli Lilly and Company; Watertown (MA); On-site; USD 168,000 - 268,000; Full time

Benefits offered by this job

Company bonus

401(k) plan

Health, dental, vision benefits

Pension

Vacation benefits

Well-being programs

Job summary

Orna Therapeutics, Inc., a Lilly subsidiary in Watertown, MA, seeks an experienced scientist to lead LC-MS/MS bioanalytical method development and validation supporting PK and biomarker assessments across drug programs.

You will design IA-LC-MS/MS methods for large molecules, oversee sample analysis campaigns, and partner with CROs and discovery teams to ensure data quality and regulatory compliance. A PhD with 3+ years in industry is required.

Qualifications

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or related scientific discipline with 3+ years of relevant industry experience
• Hands-on expertise with LC-MS/MS instrumentation for quantitative protein/peptide bioanalysis
• Experience with large molecule/biotherapeutic bioanalysis and regulatory guidance

Responsibilities

• Design, develop, and qualify LC-MS/MS methods for quantifying protein/peptide biomarkers and PK analytes in biological matrices (plasma, serum, tissue) per BMV guidance
• Lead strategy for IA-LC-MS/MS or hybrid LBA-LC-MS approaches for large-molecule analysis
• Oversee sample analysis campaigns supporting animal studies and troubleshoot matrix effects and assay robustness
• Author/review validation protocols, reports, and SOPs ensuring regulatory/compliance standards
• Serve as scientific contact for CRO partners, overseeing method transfer and data quality
• Collaborate with discovery teams for study design and data interpretation
• Present data and rationale in cross-functional settings
• Mentor junior scientists and contribute to training and process improvements

Skills

LC-MS/MS

Biomarker analysis

Analytical chemistry

Regulatory bioanalysis

Education

Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences or related

Tools

IA-LC-MS/MS

LBA-LC-MS

Job description

Orna Therapeutics, Inc., a Lilly subsidiary in Watertown, MA, seeks an experienced scientist to lead LC-MS/MS bioanalytical method development and validation supporting PK and biomarker assessments across drug programs.

You will design IA-LC-MS/MS methods for large molecules, oversee sample analysis campaigns, and partner with CROs and discovery teams to ensure data quality and regulatory compliance. A PhD with 3+ years in industry is required.