LC/MS Analytical Chemist

Pace Analytical Life Sciences; Cambridge (MA); On-site; USD 92,000 - 95,000; Full time

Job summary

Pace Analytical Life Sciences in Cambridge, MA is seeking a Scientist to perform advanced analytical development with hands-on operation of High-Resolution LC-MS. You will develop chromatographic methods (HPLC) and MS-based assays for identification, characterization, and impurity profiling of siRNA molecules, formulations, and raw materials.

Responsibilities include method development and qualification reports, SOPs, evaluating new methods, and collaborating with internal and external teams to

Qualifications

• Bachelor's or Master’s degree in Chemistry, Biology, or related field.
• 2–4 years of lab experience in a GMP environment preferred.
• Experience with Agilent Q-TOF and MassHunter is a plus.

Responsibilities

• Perform advanced analytical development with hands-on high-resolution LC-MS.
• Develop and optimize HPLC and MS-based methods for identification and impurity profiling of siRNA.
• Author method development and qualification reports and SOPs.
• Collaborate with internal and external teams to meet project timelines in a GMP environment.
• Support regulatory filings and data integrity.

Skills

Analytical chemistry

HPLC/LC-MS operation

Excellent communication

Strong organization

Education

Bachelor’s or Master’s degree in Chemistry, Biology, or related field

Tools

Agilent Q-TOF

MassHunter

Office 365

Job description

Shift:Monday through Friday, 8:00AM - 5:00PMAre you ready to work making the world a safer, healthier place? Join our mission to continuously move science forward; to innovate and advance all aspects of our business to improve the health and safety of our communities and lives.Description:The Scientist is responsible for performing advanced analytical development activities with a primary focus on hands-on operation of High-Resolution LC-MS instrumentation. This role develops and optimizes chromatographic (HPLC) and mass spectrometry-based methods to support the identification, characterization, and impurity profiling of siRNA molecules, formulations, and raw materials.Compensation: $91,500.00 - 95,000.00 per yearResponsibilities:Hands-on bench work using the High-Resolution LC-MS.Development of chromatographic methods (HPLC) and mass spectrometric based assays for identification, characterization, and impurity determination of siRNADevelop strategies for impurity profiling of new development candidates and raw materials.Author method development and qualification reports and SOP’s for test methods.Evaluate suitability of new methods, and assist method qualification and validation.Contribute data to lead candidate testing, stability sample monitoring, OOS/deviation investigation and regulatory filing.Understand and apply advanced scientific principles, theories, concepts, practices and standards to process and analytical development.Follow training to independently operate instruments and carry out routine and non-routine analysesCollaborate with internal and external teams to support project goals and meet research timelinesRequirements:Bachelor’s or Master’s degree in Chemistry, Biology, or related field2-4 years of experience in a laboratory setting (GMP environment preferred)Excellent organizational, attention to detail, and communication skills.Able to handle multiple projects concurrently, self-motivated, and results drivenExperience with Agilent Q-ToF and the MassHunter software is the plus.Proficiency in Office 365 and other software preferredFind Your Place at Pace - We need you - your curiosity, your talents, and your drive - to help us advance this important work.BenefitsWhen you join Pace, you commit to work that makes a positive impact on our communities and our world. We commit to supporting you with benefits and perks that make a positive impact on your life. Full-time roles are eligible for our comprehensive benefits program which includes competitive salaries, medical, dental vision, 401K retirement savings plan (100% vested immediately in the employer match), life, disability and voluntary benefits, paid time off for holiday, sick and vacation days, HSA, wellness program, flexible spending accounts, tuition reimbursement, Employee Assistance program, parental leave, optional legal coverage and ID theft.Equal Opportunity EmployerPace provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, creed, color, religion, genetics, protected veteran status, national origin, sex, age, disability, marital status, sexual orientation, gender identity or expression, citizenship, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.