iPSC & Brain Organoid Research Scientist

State of South Carolina; South Carolina; On-site; USD 65,000 - 95,000; Full time

Job summary

The University of South Carolina seeks an Assistant Research Scientist to establish iPSC, neuronal, and brain organoid cultures for hibernation biology studies. You will reprogram somatic cells from multiple hibernating species, optimize differentiation protocols, and perform experiments using single-cell RNA sequencing, immunohistochemistry, microscopy, Western blotting, and functional assays.

Responsibilities include experimental design, data collection/analysis, protocol development,

Qualifications

• Expertise in iPSC culture, maintenance, and manipulation.
• Experience with neuronal differentiation and stem cell-based models of neurological/neurodegenerative disease.
• Experience and knowledge of tau biology and related cellular approaches.
• Experience with immunohistochemistry, fluorescence microscopy, Western blotting, cell-based functional assays, and gene expression analysis.
• Knowledge of experimental design, data analysis, troubleshooting, and optimization of cell culture/molecular biology protocols.
• Single-cell RNA sequencing or other transcriptomic approaches desired.
• Ability to train and mentor undergraduate/graduate researchers in lab methods.
• Strong scientific writing and oral communication, including manuscripts and presentations.
• Peer-reviewed publications in stem cell biology, neuroscience, neurodegeneration, tau biology, and related fields.

Responsibilities

• Establish and maintain iPSC, neuronal, and brain organoid cultures for comparative studies of hibernation biology.
• Reprogram somatic cells from multiple hibernating species and optimize differentiation protocols.
• Conduct experiments examining cellular/molecular responses using scRNA-seq, immunohistochemistry, microscopy, Western blotting, and functional assays.
• Contribute to experimental design, data collection/analysis, protocol development/optimization, and manuscript preparation.
• Provide training and mentoring to undergraduate and graduate researchers.

Skills

iPSC culture

Neuronal differentiation

Tau biology

Immunohistochemistry

Fluorescence microscopy

Western blotting

Single-cell RNA-seq

Scientific writing

Mentoring

Publications

Education

PhD in Biology/Neuroscience or related field

Tools

Immunohistochemistry

Fluorescence microscopy

Protein analysis

RNA sequencing

Job description

The University of South Carolina seeks an Assistant Research Scientist to establish iPSC, neuronal, and brain organoid cultures for hibernation biology studies. You will reprogram somatic cells from multiple hibernating species, optimize differentiation protocols, and perform experiments using single-cell RNA sequencing, immunohistochemistry, microscopy, Western blotting, and functional assays.

Responsibilities include experimental design, data collection/analysis, protocol development,