Inflammation Principal Scientist — Translational Immunology

BioSpace; South San Francisco (CA); On-site; USD 180,000 - 260,000; Full time

Benefits offered by this job

Retirement plan

Medical, dental & vision coverage

Discretionary annual bonus

Stock-based incentives

Flexible work model

Job summary

Amgen seeks a Principal Scientist, Inflammation, to lead discovery and translational biology for an immune-targeting platform. You will drive in vitro, ex vivo, and in vivo studies, defining experimental frameworks and biomarkers to translate platform concepts into therapeutic candidates.

Collaboration across discovery, engineering, and translational safety is essential. You will develop immune cell assays, profile immune responses, and integrate data to inform candidate selection, contributing

Qualifications

• Doctorate-level degree required in a relevant biomedical field.

Responsibilities

• Lead in vitro and ex vivo immune biology strategy for a novel immune-targeting platform.
• Design and execute in vivo studies evaluating immune pharmacology in mouse models.
• Develop and optimize functional immune-cell assays and readouts.
• Build translational biology capabilities including biomarker development.
• Integrate datasets to generate mechanistic insights for platform optimization.
• Advance lead candidates with preclinical efficacy and mechanistic data.
• Collaborate across discovery biology, engineering, and translational safety teams.
• Present conclusions and document results to cross-functional teams.
• Maintain reliable, reproducible results while multitasking effectively.

Skills

Lymphocyte biology

Immune effector mechanisms

In vitro immunology

Flow cytometry

Education

PhD

MD

PharmD

Masters degree

Bachelors degree

Tools

Flow cytometry

ELISA

MSD

CRISPR/Cas9

scRNA-Seq

in vivo mouse models

Job description

Amgen seeks a Principal Scientist, Inflammation, to lead discovery and translational biology for an immune-targeting platform. You will drive in vitro, ex vivo, and in vivo studies, defining experimental frameworks and biomarkers to translate platform concepts into therapeutic candidates.

Collaboration across discovery, engineering, and translational safety is essential. You will develop immune cell assays, profile immune responses, and integrate data to inform candidate selection, contributing