In-vivo Research Associate, Immunology and Pharmacology

Pharmaessentia Corporation; Bedford (MA); On-site; USD 60,000 - 90,000; Full time

Job summary

Pharmaessentia Corporation is seeking an in vivo research associate to contribute to groundbreaking drug discovery efforts in cancer therapies at its Bedford facility. The role involves hands-on tasks in preclinical studies, maintaining cancer cell lines, and ensuring laboratory operations are efficient and effective. Ideal candidates will hold a degree in a relevant field and possess experience in in vivo pharmacology and basic laboratory techniques. Join a dedicated team focused on transforming lives through innovative research.

Benefits

Competitive 401k match

Comprehensive medical/dental/eye care benefits

Qualifications

• Hands-on experience in in vivo pharmacology studies.
• Familiarity with standard laboratory operations and IACUC protocols.
• Ability to maintain and expand cancer cell lines.

Responsibilities

• Execute tumor model studies and support pharmacology study procedures.
• Maintain day-to-day animal welfare and laboratory operations.
• Conduct data processing and prepare presentations for internal updates.

Skills

Aseptic Technique

Subcutaneous Injections

Tail Bleed

Cardiac Puncture

Xenograft Surgical Procedures

Education

B.S. or higher degree in immunology, pharmaceutical sciences or related scientific field

Job description

Job Description

The Role:
Title: In vivo research associate, Immunology and Pharmacology

Job summary:
The PharmaEssentia Innovation Research Center is building a world-class new drug discovery team in Boston area. We are seeking a highly motivated in vivo research associate to support in vivo experiment (rodent), including MTD studies, Efficacy studies, PK/PD studies and tissue harvest. You will also be asked to maintain and expand cancer cell lines to support the in vivo tumor model studies and conduct hand-on dosing and procedure support for mice pharmacology studies. In addition, you may need to support all aspects of laboratory operation to maintain a highly productive vivarium/laboratory.

The Company:
It’s not often that you get the chance to make a real impact on the lives of others, while expanding your own possibilities. You’ll find that rare opportunity at PharmaEssentia. Join us, and let’s transform lives, together.
PharmaEssentia Corporation is a rapidly growing biopharmaceutical innovator. We are leveraging deep expertise and proven scientific principles to deliver effective new biologics for challenging diseases in the areas of hematology, oncology and immunology, with one approved product and a diversifying pipeline. We believe in the potential to improve both the health and quality of life for patients with limited options today through the combination of rigorous research and innovative thinking.
Founded in 2003 by a team of Taiwanese American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung.
Our new research center, PharmaEssentia Innovation Research Center (PIRC), aims to leverage our current expertise in oncology and immunology therapeutic areas to identify and develop novel therapeutic opportunities. Therefore, we are recruiting talented scientists who have deep knowledge in immunology, translational science, bioinformatics and biologics platforms to develop novel drugs through disease-driving biology, novel technology in protein engineering, antibody discovery and new modalities.

PIRC offers a competitive benefit package, including a competitive 401k match, medical/dental/eye care benefits, and other benefits.

Summary of Key Responsibilities:

• Hand-on execute subcutaneous tumor model studies from cancer cells expansion, implantation (in mice), tumor measurement, group randomization and administration of test articles.
• Hand-on support all mice pharmacology study procedures, including but not limiting to dosing and tissue harvest.
• Follow PIRC IACUC program/protocols and standard operating procedures (SOPs) for all animal procedures.
• Maintain and expand cancer cell lines for human xenograft tumor and mouse syngeneic tumor models.
• Ensure day-to-day animal welfare, environmental quality, supply logistics, work scheduling, training, and performance management of the animal caretaking team.
• Data process and graphing for the internal team update presentation.

Essential Qualifications:

• B.S. or higher degree in immunology, pharmaceutical sciences or related scientific field

Skill	Performed in the last 2 years (includes training)
In vitro assay
ELISA	Not required, good to know
MSD	Not required, good to know
FACS	Not required, good to know
Husbandry
Aseptic Technique	Must
Micro-Isolator Technique	Must
Restraint & Handling	Must
Room Checks	Not required, good to know
Cage Change	Not required, good to know
Injections/ Administration
Subcutaneous	Must
Intraperitoneal	Must
Intravenous	Must
Intramuscular	Not required
Oral Gavage	Not required, good to know
Blood Withdrawal
Tail Bleed	Must
Cardiac Puncture	Must
Submandibular	Must
RO Bleed	Not required, good to know
Euthanasia
CO2 Overdose	Must
Cervical Dislocation	Must
Decapitation	Not required
Animal Preparation
Shaving	Must
Ear Tagging	Not required
Ear Punching/ Notching	Not required
Implantation
Xenograft SC	Must
Mammary Fat Pad	Good to know
Trocar	Not required
Anesthesia
Isoflurane Anesthesia	Not required, good to know
Lab Operations
General Organizing lab space	Must
Receiving/stocking supplies	Must
Any other duties that may arise	Must
Mammalian Cell Culture
Standard mammalian cell culture procedures and associated aseptic techniques in addition to maintenance of tissue culture facilities	Must
Media and buffer preparation, culture initiation, propagation, and cryopreservation of cells, including primary human and mouse cells and cell lines as well as adherence to quality control schedules for ensuring consistency of cell culture materials.	Must

EEO Statement:
At PharmaEssentia Innovation Research Center (PIRC), we are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. PIRC believes that diversity and inclusion among our team are critical to our success as a global company, and we seek to recruit, develop and retain the most talented people from a diverse candidate pool. PIRC does not accept unsolicited agency resumes. Staffing agencies should not send resumes to our HR team or to any PIRC employees. PIRC is not responsible for any fees related to unsolicited resumes from staffing agencies.

At PharmaEssentia, our goal is to treat as many people with cancer as possible. That means challenging the status quo with better science that leads to better lives. By joining our team, you will not only expand your own possibilities, but you will contribute to expanding options for people with cancer.

https://us.pharmaessentia.com/careers/