In Vivo Immunology Scientist I/II — Flow Cytometry Lead

Monte Rosa Therapeutics, Inc.; Boston (MA); Hybrid; USD 90,000 - 140,000; Full time

Job summary

Monte Rosa Therapeutics, Inc. seeks a Scientist I/II to advance in vivo pharmacology programs, driving translational immunology data for glue degrader programs. You will design and lead in vivo studies, perform flow cytometry, and collaborate across teams to interpret PD/PD analyses.

The role includes mentorship and coordination within an AAALAC-accredited facility. The ideal candidate has strong immunology knowledge, hands-on in vivo mouse work, and excellent communication skills, with onsite

Qualifications

• PhD in immunology, pharmacology, biology, or related field with 0–6 post-doc years, or MS with 5+ years, or BS with 8+ years.
• Strong immunology foundations including innate/adaptive responses and immune profiling data.
• Experience designing and executing in vivo pharmacology studies in mice.
• Expertise in flow cytometry with panel design and data analysis.
• Experience with blood/tissue processing and immune cell isolation.
• Experience with Western blotting including automated platforms (e.g., Jess).
• Excellent organizational skills, detail oriented, with multitasking ability.
• Excellent written and verbal communication; onsite presence 3+ days/week.

Responsibilities

• Design, execute, and independently manage in vivo pharmacology studies for target validation and MOA investigations.
• Lead preclinical study coordination across in vivo, biomarker, and discovery teams.
• Analyze, interpret, and present results to project teams and leadership.
• Troubleshoot experimental challenges and propose innovative solutions.
• Support study planning, resource allocation, and prioritization of in vivo activities.
• Perform in vivo mouse studies in inflammation, immunology, and oncology models.
• Conduct animal procedures: administration, blood collection, necropsy, tissue harvest.
• Develop and optimize multicolor flow cytometry panels and data analysis.
• Process samples for immune profiling and biomarker assessment.
• Collaborate on PD endpoints and provide mentorship to junior staff.

Skills

Flow cytometry

In vivo pharmacology

Immunology basics

Animal handling

Scientific mentorship

Education

PhD in immunology/pharmacology/biology

MS with 5+ years experience

BS with 8+ years experience

Tools

Jess

Job description

Monte Rosa Therapeutics, Inc. seeks a Scientist I/II to advance in vivo pharmacology programs, driving translational immunology data for glue degrader programs. You will design and lead in vivo studies, perform flow cytometry, and collaborate across teams to interpret PD/PD analyses.

The role includes mentorship and coordination within an AAALAC-accredited facility. The ideal candidate has strong immunology knowledge, hands-on in vivo mouse work, and excellent communication skills, with onsite