Senior Scientist, Gene Circuits & Molecular Biology

BeOne Medicines USA, Inc.; San Carlos (CA); On-site; USD 137,000 - 171,000; Full time

Job summary

BeOne Medicines Ltd. in San Carlos, CA, is seeking a Senior Scientist with expertise in Molecular Biology and Synthetic Biology to join our early discovery group.

You will design and optimize next-generation genetic payloads for cell therapy and RNA medicines, serving as a core molecular biology expert across constructs and high-throughput libraries, while collaborating with cell biologists and immunologists.

Qualifications

• Ph.D., M.S., or B.S. in Molecular Biology, Synthetic Biology, Bioengineering, Cell Biology, Immunology, or related field.
• 2+ years post-PhD, 7+ years post-M.S., or 9+ years post-B.S. in relevant experience.
• Advanced proficiency in cloning strategy, high-throughput assembly, construct design, and library generation.
• Experience with Benchling and SnapGene for construct tracking.
• Strong knowledge of lentiviral vector design and mRNA ivT workflows.
• Proven ability to work on site in San Carlos, CA.

Responsibilities

• Proactively propose and implement synthetic biology strategies (gene circuits, inducible promoters, dual-vector logic).
• Design, execute, and troubleshoot modular cloning workflows from targeted constructs to large libraries.
• Design, transcribe, and characterize ivT RNA and optimize lentiviral/AAV payloads.
• Evaluate external CRO workflows and balance internal versus outsourced work to optimize timelines and cost.
• Maintain clean plasmid archives and libraries with mapped registries.
• Collaborate with cell biologists, immunologists, and screening teams to translate payload designs into functional assays.
• Lead design reviews and communicate results to teams and leadership.

Skills

Molecular cloning

High-throughput library design

RNA biology

Flow cytometry

qPCR

NGS data analysis

Education

Ph.D. / M.S. / B.S. in Molecular Biology or related field

Tools

Benchling

SnapGene

Gibson assembly

Golden Gate

Site-directed mutagenesis

Job description

BeOne Medicines Ltd. in San Carlos, CA, is seeking a Senior Scientist with expertise in Molecular Biology and Synthetic Biology to join our early discovery group.

You will design and optimize next-generation genetic payloads for cell therapy and RNA medicines, serving as a core molecular biology expert across constructs and high-throughput libraries, while collaborating with cell biologists and immunologists.