Scientist, Early Discovery & Immunology

BeiGene, Ltd.; San Carlos (CA); On-site; USD 137,000 - 171,000; Full time

Benefits offered by this job

Equity awards

Employee Stock Purchase Plan

Medical, Dental, Vision

401(k)

Job summary

BeOne Medicines Ltd. seeks a highly motivated Scientist for their early discovery group in San Carlos, CA. You will execute cell engineering, assay, and screening workflows to advance novel biological concepts into scalable therapeutic assets.

The role requires hands-on bench work and a drug-development mindset, with collaboration across cross-functional teams to move milestones and data forward.

Qualifications

• Advanced degree with 4+ years (MS) or 6+ years (BS) in a related field and relevant experience.
• Hands-on expertise in at least two of the listed technical areas.
• Experience with flow cytometry and immune-cell functional assays.

Responsibilities

• Design, execute, and analyze experimental workflows to generate high-quality data.
• Culture, engineer, and differentiate immune cells for target validation.
• Perform flow cytometry, sorting, and functional assays to profile responses.
• Present results to cross-functional teams and leadership, contributing to strategy.

Skills

Primary T‑cell biology

iPSC culture & differentiation

Gene editing (CRISPR)

mRNA design/delivery

Flow cytometry (multicolor)

Cell sorting

Experimental design

Data analysis & interpretation

Education

PhD/MS/BS in Immunology, Cell Biology, Bioengineering, Molecular Biology

Tools

Flow cytometer

Cell sorter

qPCR

Cloning & plasmid assembly

Lentiviral or non-viral engineering

Job description

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

General Description

Candidates must be able to work onsite in San Carlos, California. At BeOne Institute, we extend BeOne’s execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles: Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles. Strategic Alignment: we prioritize disease areas that align closely with BeOne’s R&D priorities and long-term vision. Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs. At BeOne Medicines, we challenge the status quo to develop first-in-class therapies. We are seeking a highly motivated, rigorous Scientist to join our early discovery group within our agile biotech ecosystem. This role requires hands‑on laboratory execution and a drug‑development mindset. As a Scientist, you will focus on executing core cell engineering, assay, and screening workflows to move novel biological concepts into scalable therapeutic assets. You will work dynamically across diverse project initiatives, design and execute rigorous experimental strategies to modulate the immune system, and contribute cross‑functionally. We are looking for an individual who combines technical precision at the bench with a collaborative spirit and a drive to generate milestone‑moving data.

Essential Functions of the Job

• Support early discovery projects by independently designing, executing, and analyzing experimental workflows to generate high‑quality data packages.
• Perform routine and complex molecular biology techniques to support construct design, library assembly, and vector/mRNA preparation.
• Isolate, culture, and engineer primary human immune cells (such as primary T cells) and/or manage iPSC culture and differentiation workflows.
• Execute multi‑color flow cytometry, cell sorting (FACS), magnetic isolation, and quantitative immune‑cell functional assays (e.g., cell activation, cytotoxicity, cytokine profiling).
• Build, optimize, and run functional screening approaches (pooled or arrayed) to evaluate novel targets and therapeutic constructs.
• Troubleshoot technical assays, analyze biological data, and contribute experimental insight to guide project strategy and decision‑making.
• Present clear experimental results and data packages to cross‑functional project teams and discovery leadership.
• Contribute to laboratory operational workflows, technical protocols, and material management at the San Carlos site.

Supervisory Responsibilities

None

Requirements

• Travel: No Ph.D., M.S., or B.S. degree in Immunology, Cell Biology, Bioengineering, Molecular Biology, or a related scientific field, and 4+ years (M.S.), or 6+ years (B.S.) of relevant industry or academic experience.
• Demonstrated hands‑on expertise in at least two of the following key technical areas: Primary T‑cell biology iPSC culture and differentiation Gene editing modalities (CRISPR, CRISPRa/i, base editing) Lentiviral or non‑viral cell engineering mRNA design, formulation, or delivery Functional screening approaches Working knowledge of standard molecular biology techniques (e.g., cloning, qPCR, plasmid assembly).
• Hands‑on experience with multi‑color flow cytometry including panel design and primary immune‑cell functional assays.
• Proven technical proficiency with cell sorting and isolation techniques.
• Demonstrated ability to independently design and execute experiments, rigorously analyze data, and present results clearly.

Preferred

• Prior experience working in drug discovery or translational biology environments.
• Hands‑on experience processing and analyzing in vivo tissue or blood samples.
• Experience with 3D cell culture systems (e.g., organoids, tumor spheroids, or microfluidic models) to evaluate immune cell activity.
• Basic programming skills in R or Python for biological data processing and analysis.

Global Competencies

When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self‑Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results‑Oriented Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

Salary Range

Salary Range: $136,600.00 - $170,700.00 annually BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job‑related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non‑Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan.

Compensation & Benefits

All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in an Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.

Equal Opportunity

We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need.

Accommodation

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact [e-mail].

Company Overview

BeOne is a global oncology company that is discovering and developing innovative treatments that are more affordable and accessible to cancer patients worldwide. With a broad portfolio, we are expediting development of our diverse pipeline of novel therapeutics through our internal capabilities and collaborations. We are committed to radically improving access to medicines for far more patients who need them. Our growing global team of more than 11,000 colleagues spans six continents.

Learn More

To learn more about BeOne, please visit www.beonemedicines.com and follow us on LinkedIn, X (formerly known as Twitter), Facebook and Instagram. For more information, please visit the link to explore job opportunities in China Mainland.

China Mainland Job Posting

China Mainland Job Posting At BeOne, how we work is just as important as the work we do.

Values

Below are our Values that determine the decisions we make and how we do things. Patients First Driving Excellence Bold Ingenuity Collaborative Spirit