Principal Scientist, LC-MS Bioanalysis for Large Molecules

Resolian Inc.; Malvern (Chester County); On-site; USD 180,000 - 240,000; Full time

Job summary

Resolian Inc. is seeking a Principal Scientist to lead the development, validation, and application of LC-MS quantitative bioanalytical methods for large molecule therapeutics, spanning preclinical and clinical programs.

You will mentor scientists, collaborate with clients, and shape scientific strategy while advancing LC-MS technologies, ensuring compliance with GLP and regulatory expectations.

Qualifications

• Extensive GLP experience in method development and validation for large molecules.
• Proven expertise in hybrid ligand-binding assays and LC-MS quantitation.
• Hands-on experience with triple quadrupole platforms.
• Demonstrated leadership and scientist development.
• Experience presenting to clients and regulatory bodies.

Responsibilities

• Lead development and GLP validation of LC-MS bioanalytical methods for preclinical and clinical programs.
• Mentor and train a team of scientists.
• Develop, optimize, troubleshoot, and interpret methods for large molecules.
• Direct client programs and advise on design and data interpretation.
• Advance LC-MS technologies and workflows and evaluate emerging capabilities.
• Collaborate with PM, operations, QA, and regulatory teams to execute studies.
• Author and review technical and regulatory documents and present findings.
• Represent the company with BD, clients, and in the scientific community.
• Provide scientific leadership and strategic thinking.
• Demonstrate analytical problem-solving and innovation.
• Foster client and cross-functional collaboration.
• Train and mentor scientific talent; lead a small team.
• Maintain clear written and verbal scientific communication.

Skills

GLP experience

LBA and LC-MS knowledge

Triple quadrupole LC-MS

Leadership and mentorship

Client-facing skills

Regulatory knowledge (FDA/EMA/ICh)

Tools

Orbitrap

QTOF

Job description

Resolian Inc. is seeking a Principal Scientist to lead the development, validation, and application of LC-MS quantitative bioanalytical methods for large molecule therapeutics, spanning preclinical and clinical programs.

You will mentor scientists, collaborate with clients, and shape scientific strategy while advancing LC-MS technologies, ensuring compliance with GLP and regulatory expectations.