Hybrid Cryo-ET Research Fellow - Structural Biology

Instruct-ERIC; Ann Arbor (MI); Hybrid; USD 65,000 - 90,000; Full time

Job summary

University of Michigan’s Life Sciences Institute is seeking a postdoctoral research fellow to use in situ cryo-ET and cryo-CLEM to study membrane remodeling events. You will work onsite at the LSI with access to Leica Stellaris, Aquilos2, and Titan Krios G4i instruments.

Applicants should hold a Ph.D. in chemistry, physics, or related fields and have at least two years of cryo-ET experience; independence and collaboration skills are essential.

Qualifications

• Ph.D. in chemistry, physics, or a related discipline.
• Minimum of two (2) years of experience in cryo-ET data collection and processing.
• Ability to work independently and as a team player.
• Excellent communication skills.
• Minimum of 2 years of experience in continuous heterogeneity analysis and integrative modeling.

Responsibilities

• Cryo-CLEM, cryo-FIB, and cryo-ET analyses of cell lines.
• Morphometric analysis, subtomogram averaging, and integrative structural and computational analysis.
• Serial lift-out from patient tissue samples and organoid models of disease.
• Work with PI to apply for independent research funding; mentor students; assist manuscripts and grants.

Skills

Independent work

Team collaboration

Excellent communication

Education

Ph.D. in chemistry, physics, or a related discipline

Tools

Cryo-ET data collection

Cryo-ET processing

Cryo-FIB

Serial lift-out

Integrative modeling

Job description

University of Michigan’s Life Sciences Institute is seeking a postdoctoral research fellow to use in situ cryo-ET and cryo-CLEM to study membrane remodeling events. You will work onsite at the LSI with access to Leica Stellaris, Aquilos2, and Titan Krios G4i instruments.

Applicants should hold a Ph.D. in chemistry, physics, or related fields and have at least two years of cryo-ET experience; independence and collaboration skills are essential.