Research Fellow

Instruct-ERIC; Ann Arbor (MI); On-site; USD 65,000 - 90,000; Full time

Job summary

University of Michigan’s Life Sciences Institute is seeking a postdoctoral research fellow to use in situ cryo-ET and cryo-CLEM to study membrane remodeling events. You will work onsite at the LSI with access to Leica Stellaris, Aquilos2, and Titan Krios G4i instruments.

Applicants should hold a Ph.D. in chemistry, physics, or related fields and have at least two years of cryo-ET experience; independence and collaboration skills are essential.

Qualifications

• Ph.D. in chemistry, physics, or a related discipline.
• Minimum of two (2) years of experience in cryo-ET data collection and processing.
• Ability to work independently and as a team player.
• Excellent communication skills.
• Minimum of 2 years of experience in continuous heterogeneity analysis and integrative modeling.

Responsibilities

• Cryo-CLEM, cryo-FIB, and cryo-ET analyses of cell lines.
• Morphometric analysis, subtomogram averaging, and integrative structural and computational analysis.
• Serial lift-out from patient tissue samples and organoid models of disease.
• Work with PI to apply for independent research funding; mentor students; assist manuscripts and grants.

Skills

Independent work

Team collaboration

Excellent communication

Education

Ph.D. in chemistry, physics, or a related discipline

Tools

Cryo-ET data collection

Cryo-ET processing

Cryo-FIB

Serial lift-out

Integrative modeling

Job description

Jobs in Structural Biology and Related Fields

Research Fellow

University of Michigan, United States

The Life Sciences Institute explores biological processes, structures, and functions at the finest scale to create impact on a global scale.

The Mosalaganti lab at the Life Sciences Institute (LSI) is seeking an outstanding postdoctoral research fellow interested in using in situ cryo-electron tomography (cryo-ET) in conjunction with cryo-CLEM to address membrane remodeling events. You will have unencumbered access to our Leica Stellaris cryo-confocal, Aquilos2, Titan Krios G4i (with K3, BioQuantum imaging filter, and phase plate) housed on-site. Candidates should have the following: (1) a strong background in structural biology/biophysics, (2) a sense of independence, and (3) be motivated to push the boundaries of structural biology. You will report directly to Dr. Mosalaganti and perform your work onsite at the LSI.

Responsibilities

Experimental responsibilities will include:

• Cryo-CLEM, cryo-FIB, and cryo-ET analyses of cell lines.
• Morphometric analysis, subtomogram averaging, and integrative structural and computational analysis.
• Serial lift-out from patient tissue samples and organoid models of disease.

Non-Experimental responsibilities will include:

• Work with PI to apply for independent research funding.
• Work/collaborate with other postdoctoral fellows and graduate students in and outside of the laboratory.
• Mentor undergraduates and graduate students in the laboratory.
• Assist PI with writing manuscripts and grants.

Required Qualifications

• Ph.D. in chemistry, physics, or a related discipline
• Minimum of two (2) years of experience in cryo-ET data collection and processing
• Ability to work independently and as a team player
• Excellent communication skills

Desired Qualifications

• Minimum of 2 years of experience in continuous heterogeneity analysis and integrative modeling.

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

For more information, please contact Dr. Mosalaganti at [e-mail]

Application Deadline:
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled any time after the minimum posting period has ended.