HPLC Method Development Scientist I/II (Bioanalytical)

Pharmaron Beijing Co. Ltd.; Exton (PA); On-site; USD 55,000 - 65,000; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

401(k) Plan

Paid Time Off

Job summary

Pharmaron's Bioanalytical Sciences team in Exton, PA is seeking a Scientist I/II – HPLC Method Development to develop, optimize, troubleshoot, and validate chromatographic methods for drug discovery and development programs. The role offers hands-on experience across HPLC and related platforms in a global CRO/CDMO setting.

Ideal candidates have 1–3+ years of relevant analytical experience and a strong foundation in chromatographic principles, data analysis, and documentation.

Qualifications

• Bachelor's degree or higher in Analytical Chemistry, Chemistry, Pharmaceutical Sciences, Biochemistry, or a related scientific discipline.
• 1–3+ years of relevant analytical or bioanalytical laboratory experience; position level will be determined based on experience and demonstrated technical capabilities.
• Hands-on experience developing, optimizing, and/or troubleshooting HPLC/ LCMS methods.
• Strong understanding of chromatographic principles, including separation, selectivity, retention, resolution, and method optimization.
• Experience analyzing and interpreting chromatographic data and troubleshooting analytical challenges.
• Strong analytical thinking and scientific problem-solving capabilities.
• Ability to accurately document and communicate experimental procedures, results, and conclusions.
• Strong organizational skills, attention to detail, and ability to work effectively in a fast-paced, collaborative scientific environment.

Responsibilities

• Develop, optimize, troubleshoot, and validate HPLC-based analytical and bioanalytical methods.
• Design and optimize chromatographic conditions, including column selection, mobile phases, gradients, flow rates, and other method parameters.
• Troubleshoot chromatographic challenges related to peak shape, resolution, selectivity, sensitivity, carryover, retention, and method performance.
• Perform analytical and bioanalytical sample analysis using HPLC and other available analytical platforms.
• Design and execute scientifically sound experiments aligned with study requirements, client objectives, and internal quality standards.
• Process, analyze, interpret, and report chromatographic data while identifying and resolving technical challenges.
• Support method qualification and validation activities and ensure appropriate scientific documentation of experimental procedures and results.
• Review and execute study protocols and contribute to protocols, validation reports, technical summaries, study reports, and other scientific documentation.
• Support developmental and regulated laboratory activities in accordance with applicable procedures and quality requirements.
• Collaborate with scientists, project teams, management, Business Development, and clients to support successful project execution.
• Participate in scientific project reviews, technical discussions, troubleshooting activities, and continuous improvement initiatives.
• Gain exposure to advanced bioanalytical and mass spectrometry applications as experience and project needs develop.

Skills

HPLC method development

LCMS methods

Chromatographic data analysis

Analytical problem solving

Documentation

Education

Bachelor's degree in Analytical Chemistry

Chemistry/Pharmaceutical Sciences/Biochemistry

Tools

HPLC instrumentation

UHPLC instrumentation

Chromatographic software

LC-MS software

Job description

Pharmaron's Bioanalytical Sciences team in Exton, PA is seeking a Scientist I/II – HPLC Method Development to develop, optimize, troubleshoot, and validate chromatographic methods for drug discovery and development programs. The role offers hands-on experience across HPLC and related platforms in a global CRO/CDMO setting.

Ideal candidates have 1–3+ years of relevant analytical experience and a strong foundation in chromatographic principles, data analysis, and documentation.