High-Throughput Chemistry Scientist II – Direct-to-Biology

Jnana Therapeutics Inc.; Boston (MA); On-site; USD 110,000 - 158,000; Full time

Job summary

Jnana Therapeutics, a Boston-based biotechnology company, seeks a Scientist for Discovery Chemistry to advance drug discovery programs targeting hard-to-drug proteins using our RAPID chemoproteomics platform.

The role focuses on direct-to-biology chemistry, high-throughput screening, and synthesis of novel small molecules, with collaboration across disciplines and with CRO partners. A PhD with relevant experience is required, along with strong communication and organizational skills.

Qualifications

• Ph.D. in Medicinal Chemistry, Organic Chemistry, or closely related field.
• 0–2 years industry experience in parallel synthesis, liquid handling and high-throughput experimentation.
• Passion for drug discovery, strong organization and excellent communication skills.

Responsibilities

• Execute direct-to-biology, high-throughput chemistry to support the platform.
• Develop and optimize new reactions for direct-to-biology chemistry.
• Establish high-throughput chemistry function and assist in planning/building laboratory automation.
• Utilize synthetic expertise to design and synthesize target molecules.
• Collaborate with external chemistry CROs to synthesize target molecules.
• Work across scientific disciplines on multiple projects.
• Engage in brainstorming and generation of new ideas across projects.
• Assist in preparing patent applications and publications.
• Maintain a safe, productive laboratory environment.

Skills

Direct-to-biology chemistry

High-throughput chemistry

Parallel synthesis

Liquid handling

Synthesis design

Education

Ph.D. in Medicinal Chemistry

Ph.D. in Organic Chemistry

Job description

Jnana Therapeutics, a Boston-based biotechnology company, seeks a Scientist for Discovery Chemistry to advance drug discovery programs targeting hard-to-drug proteins using our RAPID chemoproteomics platform.

The role focuses on direct-to-biology chemistry, high-throughput screening, and synthesis of novel small molecules, with collaboration across disciplines and with CRO partners. A PhD with relevant experience is required, along with strong communication and organizational skills.