Head of Quantitative Pharmacology & Pharmacometrics - Oncology

Merck; Upper Gwynedd Township (Montgomery County); Hybrid; USD 260,000 - 460,000; Full time

Job summary

Merck seeks a Head of Quantitative Pharmacology & Pharmacometrics (QP2) to lead pharmacology strategy for the oncology pipeline, integrating data and advanced analytics to guide dose, schedule, and patient selection. The leader will shape program design, supervision of scientists, and regulatory interactions, building a modern quantitative operating model for oncology development.

The role requires a Ph.D. with at least 15 years in drug development, including 5+ years in oncology, and a strong

Qualifications

• Ph.D. or equivalent in biopharmaceutics, pharmaceutical sciences, pharmacometrics, mathematics, statistics/biostatistics, computational biology/chemistry, chemical/biomedical engineering, or related field.
• At least 15 years in drug development with ≥5 years in oncology in industry.
• Experience leading quantitative science to shape program design and regulatory strategy.

Responsibilities

• Lead pharmacology strategy for oncology pipeline and drive model-informed decisions.
• Oversee and mentor scientific staff; govern QP2 strategy and operating model.
• Interact with regulatory teams and lead portfolio-level decision making.

Skills

Quantitative pharmacology

Pharmacometrics

Model-informed drug development

Population PK/PKPD analysis

Regulatory strategy

Interdisciplinary leadership

AI/ML in drug development

Education

Ph.D. or equivalent degree

15+ years in drug development

Oncology experience in industry

Job description

Merck seeks a Head of Quantitative Pharmacology & Pharmacometrics (QP2) to lead pharmacology strategy for the oncology pipeline, integrating data and advanced analytics to guide dose, schedule, and patient selection. The leader will shape program design, supervision of scientists, and regulatory interactions, building a modern quantitative operating model for oncology development.

The role requires a Ph.D. with at least 15 years in drug development, including 5+ years in oncology, and a strong