Head of Pharmacogenomics (PGx)

OpenKrill; United States; On-site; USD 206,000 - 265,000; Full time

Benefits offered by this job

Health Insurance

Remote options for many roles

Parental Leave

Job summary

Helix is seeking a Head of Pharmacogenomics to define the growth strategy for its PGx business, aligning with health systems and health plans to drive adoption of pharmacogenomics in clinical practice. You will shape the product roadmap and ROI models, ensuring PGx capabilities are integrated into care pathways and partnerships.

You will lead cross-functional teams across Commercial, Product, Medical, and Operations, engage with executives, and translate clinical evidence into scalable,

Qualifications

• Pharmacogenomics, precision medicine, clinical digital health, or a related product/commercial role in PGx or precision medicine.
• Experience leading enterprise conversations with health-system or health-plan executives and building a clear clinical/economic case for adoption.
• Strong understanding of EHR integration, clinical decision support, and physician/pharmacist workflows.
• Ability to translate customer/clinical needs into product priorities and commercial strategies.
• Clear, credible communicator across clinical, commercial, product, and technical teams.
• AI tools to synthesize literature, model ROI, and accelerate customer deliverables.

Responsibilities

• Own the PGx business mandate and growth strategy across health systems and health plans.
• Develop and communicate ROI models demonstrating PGx value across fee-for-service and risk-bearing arrangements.
• Represent Helix in conversations with health-system and health-plan executives, pharmacy leaders, and clinical teams to design and deploy enterprise PGx programs.
• Shape the product roadmap to include EHR-embedded CDS, patient identification, drug-gene interaction alerting, and pharmacist workflows.
• Guide commercial direction by partnering with Marketing and Business Development to align customer priorities with PGx value proposition.
• Interpret clinical and market insights to identify new product and business opportunities.

Skills

Pharmacogenomics

EHR integration

Stakeholder management

ROI modeling

Clinical decision support

Education

PharmD, MD, or advanced degree in a related field

Tools

EHR systems

Job description

Who We Are & What We Do

At Helix, our mission is simple: to help everyone improve their lives through their DNA.

Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.

As the business leader for pharmacogenomics at Helix, you’ll define what we build, how our solutions are put into practice, and how the PGx business grows. Working across Commercial, Product, Medical, and Operations, you’ll shape our go-to-market strategy, influence the product roadmap, and engage directly with health-system and health-plan leaders to turn PGx capabilities into products and partnerships that improve care and lower the cost of care.

Why this role is different

• Shape the future of PGx adoption: Helix’s Sequence Once, Query Often model makes genomic insights available on demand at the point of care. You’ll build on that advantage to define how health systems and health plans use PGx to inform medication decisions, and create the products and partnerships that make PGx a standard part of patient care
• A builder’s mandate: You’ll have the opportunity to shape a growing business from the ground up, with a direct connection between customer needs, product decisions, commercial strategy, and clinical adoption
• Find and Build High-Value PGx Use Cases: Working closely with customers, you’ll identify patient populations where PGx can improve care and lower total cost of care, then turn those opportunities into compelling value propositions and scalable rollout plans

As Head of Pharmacogenomics at Helix, you will:

• Own the PGx business mandate: Set the growth strategy for Helix’s PGx business, with accountability for product adoption and customer engagement across health systems and health plans
• Develop compelling PGx ROI models: Inform the design of ROI models that demonstrate the economic value of PGx across fee-for-service and risk-bearing organizations
• Serve as the external subject matter expert: Represent Helix in conversations with health system and health plan executives, pharmacy leaders, and clinical teams to design and deploy enterprise PGx programs
• Shape the product roadmap: Translate customer and clinical needs into product priorities, including EHR-embedded Clinical Decision Support, patient identification, drug-gene interaction alerting, and pharmacist workflows
• Guide commercial direction: Partner with Marketing and Business Development to inform target customer priorities and the Helix PGx value proposition, ensuring go-to-market plans reflect business goals, customer needs, and product development priorities
• Inform strategy through clinical and market Insight: Track evolving clinical guidelines,, reimbursement trends, and developments in PGx to identify new product and commercial opportunities

About you

• 7+ years of experience in pharmacogenomics, precision medicine, clinical digital health, or a related product or commercial role, ideally at a PGx or precision medicine company
• Experience leading complex enterprise conversations with health system or health plan executives and building a clear clinical and economic case for adoption
• Strong understanding of EHR integration, clinical decision support, and physician and pharmacist workflows
• Ability to translate customer and clinical needs into product priorities and commercial strategies
• Clear, credible communicator who can work effectively across clinical, commercial, product, and technical teams
• AI tools are a natural part of how you work – to synthesize clinical literature, model ROI scenarios, and move faster on customer deliverables

The ideal candidate will have:

• PharmD, MD, or advanced degree in a relevant clinical, scientific, or health related field
• Experience in health system pharmacy, comprehensive medication management, or clinical decision support
• Experience developing health economic models, ROI cases, reimbursement strategies, or value-based commercial arrangements

Expected Interview Process:

Expected Interview Process:1) Recruiter Screen 2) Manager Screen/Tech Screen 3) Onsite 4) Offer

Expected Pay For This Role:

• Expected Helix Base: $206,000 - $265,000
• Expected Helix Discretionary Annual Bonus: 20% of your annual salary
• Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.

Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:

• Comprehensive Health Insurance with Date of Hire eligibility
• Above average employer paid premium coverage
• 12 weeks Helix Paid Parental Leave option
• 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
• Comprehensive Well-Being Benefits
• Flexible PTO
• Remote options for many roles and a home office stipend

What To Expect During Your First 90 days:

• First 30 days: you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.
• Day 30 - 60: you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.
• Day 60 - 90: you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.

CompensationThe base pay range for this role is $206,000 – $265,000 per year.

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Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.

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