Head of Pharmacogenomics (PGx)

Helix; Northern (KY); Hybrid; USD 206,000 - 265,000; Full time

Benefits offered by this job

Health insurance

Remote options for many roles

Home office stipend

Job summary

Helix is seeking a Head of Pharmacogenomics to lead the PGx business, shaping strategy and product adoption across health systems and health plans. You will translate clinical and economic value into enterprise programs and partnerships, collaborating with commercial, product, and medical teams to drive scalable PGx solutions.

You will build ROI models, engage executives, and guide the roadmap for EHR-embedded decision support and pharmacist workflows, while staying ahead of evolving guidelines

Qualifications

• 7+ years in pharmacogenomics, precision medicine, clinical digital health, or related product/commerce role
• Experience leading enterprise conversations with health-system or health-plan executives
• Strong understanding of EHR integration, CDS, and clinician workflows
• Ability to translate customer/clinical needs into product priorities and commercial strategies
• Clear, credible communicator across clinical, commercial, product, and technical teams
• AI tools to synthesize literature, model ROI, and accelerate deliverables

Responsibilities

• Own growth strategy for Helix PGx business across health systems and health plans
• Develop ROI models demonstrating PGx value across fee-for-service and risk-bearing organizations
• Represent Helix with health-system executives, pharmacy and clinical leaders
• Shape product roadmap including EHR-embedded CDS and pharmacist workflows
• Define GTM motions with Marketing and BizDev to drive adoption
• Monitor guidelines and reimbursement trends to identify new opportunities

Skills

Pharmacogenomics

Health-system engagement

EHR integration

Clinical decision support

ROI modeling

Communication

AI-enabled analysis

Education

PharmD or MD

Advanced clinical degree

Tools

EMR/EBM tools

Job description

Who We Are & What We Do

At Helix, our mission is simple: to help everyone improve their lives through their DNA.

Ready to make a real-world impact with your skills? At Helix, we're transforming healthcare by making genomics a standard of care. We partner with health systems and life science companies to accelerate the integration of genomic data into clinical practice. Join us in building a future where healthcare is personalized, proactive, and powered by genomics.

As the business leader for pharmacogenomics at Helix, you’ll define what we build, how our solutions are put into practice, and how the PGx business grows. Working across Commercial, Product, Medical, and Operations, you’ll shape our go-to-market strategy, influence the product roadmap, and engage directly with health-system and health-plan leaders to turn PGx capabilities into products and partnerships that improve care and lower the cost of care.

Why this role is different

• Shape the future of PGx adoption: Helix’s Sequence Once, Query Often® model makes genomic insights available on demand at the point of care. You’ll build on that advantage to define how health systems and health plans use PGx to inform medication decisions, and create the products and partnerships that make PGx a standard part of patient care
• A builder’s mandate: You’ll have the opportunity to shape a growing business from the ground up, with a direct connection between customer needs, product decisions, commercial strategy, and clinical adoption
• Find and Build High-Value PGx Use Cases: Working closely with customers, you’ll identify patient populations where PGx can improve care and lower total cost of care, then turn those opportunities into compelling value propositions and scalable rollout plans

As Head of Pharmacogenomics at Helix, you will:

• Own the PGx business mandate: Set the growth strategy for Helix’s PGx business, with accountability for product adoption and customer engagement across health systems and health plans
• Develop compelling PGx ROI models: Inform the design of ROI models that demonstrate the economic value of PGx across fee-for-service and risk-bearing organizations
• Serve as the external subject matter expert: Represent Helix in conversations with health system and health plan executives, pharmacy leaders, and clinical teams to design and deploy enterprise PGx programs
• Shape the product roadmap: Translate customer and clinical needs into product priorities, including EHR-embedded Clinical Decision Support, patient identification, drug-gene interaction alerting, and pharmacist workflows
• Build the go-to-market motion: Partner with Marketing and Business Development to define target customers, sharpen the Helix PGx value proposition, and create the materials and commercial strategies that turn interest into adoption
• Inform strategy through clinical and market Insight: Track evolving clinical guidelines,, reimbursement trends, and developments in PGx to identify new product and commercial opportunities

About you

• 7+ years of experience in pharmacogenomics, precision medicine, clinical digital health, or a related product or commercial role, ideally at a PGx or precision medicine company
• Experience leading complex enterprise conversations with health system or health plan executives and building a clear clinical and economic case for adoption
• Strong understanding of EHR integration, clinical decision support, and physician and pharmacist workflows
• Ability to translate customer and clinical needs into product priorities and commercial strategies
• Clear, credible communicator who can work effectively across clinical, commercial, product, and technical teams
• AI tools are a natural part of how you work – to synthesize clinical literature, model ROI scenarios, and move faster on customer deliverables

The ideal candidate will have:

• PharmD, MD, or advanced degree in a relevant clinical, scientific, or health related field
• Experience in health system pharmacy, comprehensive medication management, or clinical decision support
• Experience developing health economic models, ROI cases, reimbursement strategies, or value-based commercial arrangements

Expected Interview Process:

1) Recruiter Screen2) Manager Screen/Tech Screen3)Onsite4)Offer

Expected Pay For This Role:

There are 3 distinct parts to your Helix offer:1)Base Salary2)Annual Bonus3)Equity

• Expected Helix Base: $206,000 - $265,000
• Expected Helix Discretionary Annual Bonus: 20% of your annual salary
• Equity: We offer generous equity at Helix. If you receive a Helix offer your recruiter will book dedicated time with you to educate you on our equity model.

Aside from working alongside brilliant, dedicated, passionate, down-to-earth, curious, warm, and thoughtful people, we also provide great benefits:

• Comprehensive Health Insurance with Date of Hire eligibility
  • Above average employer paid premium coverage
• 12 weeks Helix Paid Parental Leave option
• 401(k) with employer matching of up to 3% and 100% Vesting on the Date of Hire
• Comprehensive Well-Being Benefits
• Flexible PTO
• Remote options for many roles and a home office stipend

What To Expect During Your First 90 days:

• First 30 days:you’ll spend time learning the Helix way, completing training and onboarding for your roles, and getting introduced to your team and relevant stakeholders. You’ll also gain a deeper understanding of our customers, our products, the impact we make in the lives of our communities, and how to thrive at Helix through participation in Helix U.
• Day 30 - 60:you’ll spend time contributing to projects, deeply familiarizing yourself with team and company processes, and developing a deeper understanding of Helix’s products, services and capabilities.
• Day 60 - 90:you’ll build your OKRs with your manager, start to take ownership of projects and initiatives on your team, and begin to demonstrate your impact on the Helix mission.

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Helix is proud to be an equal opportunity employer, and committed to providing employment opportunities regardless of race, religious creed, color, national origin, ancestry, physical disability, mental disability, medical condition, genetic information, marital status, sex, gender, gender identity, gender expression, pregnancy, childbirth and breastfeeding, age, sexual orientation, military or veteran status, or any other protected classification, in accordance with applicable federal, state, and local laws.