Global Payroll Manager — Multi-State & UK Expert

Xairatherapeutics; South San Francisco (CA); On-site; USD 135,000 - 160,000; Full time

Job summary

Xaira Therapeutics, based in the San Francisco Bay Area, seeks a hands-on Payroll Manager to lead end-to-end payroll for US and UK employees. You will ensure accurate, on-time payments and regulatory compliance while partnering with HR, Accounting, and external providers.

The role focuses on maintaining payroll systems, implementing improvements, and building scalable processes to support long-term growth. Strong Excel, ERP, and payroll-law knowledge are essential.

Qualifications

• Bachelor's degree in Accounting, Finance, Business Administration, Human Resources, or related field.
• 5+ years of payroll experience, including multi-state payroll.
• Experience administering employee expense reimbursement and corporate credit card programs.
• Strong knowledge of U.S. payroll tax regulations and wage-and-hour laws.
• Experience with payroll and expense management systems (e.g., ADP, UKG Ready, Concur, Ramp, or similar).
• Advanced Microsoft Excel skills.
• Excellent analytical, organizational, and problem-solving skills.
• Strong attention to detail and ability to handle confidential information.
• Experience with ERP systems such as NetSuite is preferred.

Responsibilities

• Manage end-to-end payroll process for all employees, including regular payroll, bonuses, and off-cycle payments.
• Ensure timely and accurate processing of multi-state payroll.
• Review payroll registers and perform reconciliations across US and UK jurisdictions.
• Maintain payroll calendars and meet deadlines.
• Process hires, terminations, salary adjustments, promotions, and other payroll changes.
• Administer LOA payroll calculations and related deductions per policy and law.
• Respond to employee payroll inquiries professionally and confidentially.
• Resolve payroll discrepancies promptly.

Skills

Advanced Microsoft Excel

Analytical

Organizational

Problem-solving

Attention to detail

Confidentiality

Communication

Education

Bachelor's degree in Accounting, Finance, Business Administration, Human Resources, or related field

Tools

ADP

UKG Ready

Concur

Ramp

NetSuite

Job description

Xaira Therapeutics, based in the San Francisco Bay Area, seeks a hands-on Payroll Manager to lead end-to-end payroll for US and UK employees. You will ensure accurate, on-time payments and regulatory compliance while partnering with HR, Accounting, and external providers.

The role focuses on maintaining payroll systems, implementing improvements, and building scalable processes to support long-term growth. Strong Excel, ERP, and payroll-law knowledge are essential.