Global GI & Rare Disease Franchise Leader

Alfasigma; Union (NJ); Remote; USD 202,000 - 269,000; Full time

Job summary

Alfasigma is seeking a Sr. Director, Global Franchise Head for Gastroenterology & Rare Disease to define and execute the global therapeutic area strategy, leading brand planning, resource allocation, and cross-functional collaboration with R&D, Medical Affairs, and Commercial teams.

The role focuses on maximizing long-term franchise value, delivering sustainable growth, and building a high-performing team across global markets with regional partners.

Qualifications

• Significant international pharmaceutical experience in Marketing, Franchise Leadership, or General Management.
• Proven track record in Gastroenterology and Rare Diseases.
• Experience defining and executing Therapeutic Area strategies.
• Strong strategic thinking with execution excellence.
• Experience leading cross-functional, matrix-based global organizations.
• Strong people leadership and talent development capabilities.
• Excellent influencing, communication, and stakeholder management skills.

Responsibilities

• Define and co-lead the long-term Gastroenterology & Rare Disease Therapeutic Area Strategy with R&D, leveraging key stakeholders across Medical Affairs, Business Development, Market Access, and Commercial functions.
• Translate scientific, competitive, and market insights into where to play and how to win franchise strategy.
• Align pipeline development, lifecycle management opportunities, licensing opportunities, and commercial priorities.
• Drive cross-functional decision-making to maximize asset value.
• Establish a sustainable franchise vision that extends beyond brands, indications, and disease areas.
• Define and implement best-in-class global brand plans across Gastroenterology & Rare Disease assets.
• Lead franchise budgeting and investment prioritization processes.
• Identify growth opportunities and manage lifecycle strategies across the portfolio.
• Partner with BD and R&D to maximize external innovation opportunities.

Skills

International pharma experience

Gastroenterology

Rare diseases

Strategic thinking

Leadership

Stakeholder management

Cross-functional leadership

Job description

Alfasigma is seeking a Sr. Director, Global Franchise Head for Gastroenterology & Rare Disease to define and execute the global therapeutic area strategy, leading brand planning, resource allocation, and cross-functional collaboration with R&D, Medical Affairs, and Commercial teams.

The role focuses on maximizing long-term franchise value, delivering sustainable growth, and building a high-performing team across global markets with regional partners.