Executive Director, Translational PK/PD for Genetic Meds

BioSpace; Indianapolis (IN); On-site; USD 177,000 - 308,000; Full time

Job summary

Lilly in Indianapolis seeks a Scientific Director to lead mechanistic PK/PD modeling for novel modalities. You will guide genetic medicines PK/PD programs (ASOs, siRNA, LNPs, gene therapy, ARC) and shape translational strategies through quantitative approaches.

The role requires a PhD with 5+ years of industry/CRO experience, deep modeling expertise (NONMEM, mrgsolve, MATLAB, Monolix, SimCYP, PKSim), and strong collaboration across teams.

Qualifications

• PhD in Pharmacokinetics/Pharmacodynamics, Pharmacology, Pharmaceutical Sciences, Biomedical engineering, or a related subject area with experience applying quantitative approaches, with at least 5 years of industry/CRO experience in translational and/or mechanistic PKPD modeling.
• Experience with empirical or mechanistic PK/PD modeling to support drug discovery and/or development.
• Experience with DMPK and translational PK/PD modeling to support interspecies scaling, human dose projections, and first-in-human study design.
• Experience with computational modeling and simulation software such as NONMEM, mrgsolve, MATLAB, Monolix, SimCYP, PKSim, or equivalent platforms.
• Experience working effectively in a cross-functional, matrixed collaborative environment.

Responsibilities

• Serve as the Discovery PKPD project leader for genetic medicines programs, including ASOs, siRNA, LNP-mediated delivery, gene therapy (AAV and non-viral vectors), and antibody-siRNA conjugates (ARC).
• Develop and implement modeling strategies that enhance decision-making for genetic medicines informing translational research strategies.
• Design, analyze, and interpret quantitative pharmacology and PK/PD studies.
• Collaborate with scientists inside and outside the function to integrate PK/PD into team strategy and guide go/no-go decisions with quantitative approaches.
• Communicate quantitative findings through publications, conferences, and cross-functional forums.
• Mentor junior scientists and contribute to growing PKPD modeling capabilities within genetic medicines and neuroscience spaces.

Skills

Quantitative pharmacology

Cross-functional collaboration

Scientific leadership

Education

PhD in Pharmacokinetics/Pharmacodynamics, Pharmacology, Pharmaceutical Sciences, Biomedical engineering, or related field

Tools

NONMEM

mrgsolve

MATLAB

Monolix

SimCYP

PK-Sim

Job description

Lilly in Indianapolis seeks a Scientific Director to lead mechanistic PK/PD modeling for novel modalities. You will guide genetic medicines PK/PD programs (ASOs, siRNA, LNPs, gene therapy, ARC) and shape translational strategies through quantitative approaches.

The role requires a PhD with 5+ years of industry/CRO experience, deep modeling expertise (NONMEM, mrgsolve, MATLAB, Monolix, SimCYP, PKSim), and strong collaboration across teams.