Executive Director, Clinical Science & Trials

Madrigal Pharmaceuticals; Conshohocken (Montgomery County); On-site; USD 288,000 - 352,000; Full time

Benefits offered by this job

Equity

Comprehensive benefits

401(k) with match

Mental health support

Flexible paid time off

Job summary

Madrigal Pharmaceuticals is seeking an Executive Director, Clinical Scientist to lead clinical strategy for MASH assets. You will drive trial design, data interpretation, and regulatory submissions, collaborating with cross-functional teams to advance programs through clinical development.

The role requires deep experience in clinical research and regulatory knowledge, with leadership responsibilities reporting to the VP of Clinical Development.

Qualifications

• Advanced life sciences degree required; PhD/MD/PharmD or equivalent.
• 12+ years of clinical development or clinical research experience in pharma/biotech.
• 18+ years of relevant experience; strong knowledge of ICH/GCP and global clinical trial regulations.

Responsibilities

• Design and develop clinical trial protocols with scientific rationale, objectives, endpoints and eligibility criteria.
• Author or review investigator brochures, informed consent forms, CSRs, and regulatory submissions.
• Provide scientific input during trial execution, including protocol amendments, site engagement, data reviews and ongoing study support.
• Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure high-quality trial conduct and data integrity.
• Conduct data reviews and support data interpretation in collaboration with biostatistics and the medical team.
• Prepare documents for regulatory submissions, health authority meetings and internal governance presentations.
• Stay current on therapeutic area trends, regulatory guidance related to MASH/NASH and related comorbidity developments.
• Participate in cross-functional meetings and contribute to development strategies and timelines.

Skills

Clinical development

Cross-functional collaboration

ICH/GCP knowledge

Scientific communication

Regulatory submissions

Education

PhD/MD/PharmD

Master’s degree with relevant experience

Job description

Madrigal Pharmaceuticals is seeking an Executive Director, Clinical Scientist to lead clinical strategy for MASH assets. You will drive trial design, data interpretation, and regulatory submissions, collaborating with cross-functional teams to advance programs through clinical development.

The role requires deep experience in clinical research and regulatory knowledge, with leadership responsibilities reporting to the VP of Clinical Development.