DMPK Scientist: PK/PD Modeling for RNA Therapies

Alnylam Pharmaceuticals, Inc.; Cambridge (MA); On-site; USD 110,000 - 166,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Life and disability insurance

401(k) with company match

Paid time off and holidays

Wellness days and recharge breaks

Job summary

Alnylam Pharmaceuticals, Inc. in Cambridge, MA is seeking a DMPK Scientist to design and interpret in vitro and in vivo ADME and PK/PD studies for siRNA and other modalities, informing human dose projections and candidate selection.

You will build quantitative models and simulations using Phoenix WinNonlin, Monolix, and R, integrate PK/PD and biomarker data, collaborate with cross-functional teams, and prepare analyses and regulatory submissions.

Qualifications

• Ph.D. in pharmaceutical sciences or related quantitative field with 0+ years, or Masters with 5+ years, or Bachelors with 10+ years in DMPK.
• Strong foundation in quantitative pharmacology and PK/PD with hands-on data analysis.
• Exposure to PBPK, population PK, or systems pharmacology modeling is a plus.
• Proficiency with modeling and programming tools (Phoenix WinNonlin, Monolix, R).
• Solid understanding of ADME principles and drug discovery and development; knowledge of oligonucleotide therapeutics a plus.
• Excellent problem solving, communication, and collaboration skills.

Responsibilities

• Support DMPK strategy across drug discovery and development by designing, executing, and interpreting in vitro and in vivo ADME and PK/PD studies for siRNA and other therapeutic modalities.
• Apply quantitative pharmacology approaches—including non-compartmental analysis, compartmental PK/PD, PBPK, and mechanistic/systems modeling—to characterize drug disposition and exposure–response relationships.
• Integrate PK, PD, and biomarker data to inform candidate selection, human dose projection, and first-in-human dose predictions.
• Build, qualify, and clearly document models and simulations using tools such as Phoenix WinNonlin, Monolix, R, and other equivalent tools.
• Contribute to the design of preclinical and translational studies that support progression of candidates from discovery through clinical development.
• Collaborate with cross-functional project teams (bioanalysis, chemistry, biology, toxicology, and clinical pharmacology) to analyze data and communicate quantitative pharmacology insights.
• Prepare clear, well-documented analyses, reports, and presentations, and contribute to regulatory submissions as needed.
• Complete projects in a timely and clearly documented manner while maintaining high scientific and data-quality standards.
• Stay current with emerging modeling methodologies and scientific literature to continuously strengthen the team’s quantitative capabilities.

Skills

Quantitative pharmacology

PK/PD modeling

Non-compartmental analysis

Compartmental PK/PD

PBPK

Systems pharmacology

Monolix

Phoenix WinNonlin

R

Education

PhD in pharmaceutical sciences

MS in related quantitative discipline

Tools

Phoenix WinNonlin

Monolix

R

Job description

Alnylam Pharmaceuticals, Inc. in Cambridge, MA is seeking a DMPK Scientist to design and interpret in vitro and in vivo ADME and PK/PD studies for siRNA and other modalities, informing human dose projections and candidate selection.

You will build quantitative models and simulations using Phoenix WinNonlin, Monolix, and R, integrate PK/PD and biomarker data, collaborate with cross-functional teams, and prepare analyses and regulatory submissions.