Director of ADME & PK Strategy

BioSpace; Indianapolis (IN); On-site; USD 177,000 - 308,000; Full time

Job summary

Lilly is seeking an experienced pharmaceutical scientist to lead ADME science across diverse modalities, including small molecules and biologics. The role involves guiding experimental design, data interpretation, and cross-functional collaboration to advance candidates toward global submissions.

The position requires a Ph.D. with 6+ years of ADME/drug metabolism expertise, strong communication, and the ability to manage multiple projects while partnering with discovery, toxicology, and

Qualifications

• Ph.D. degree in Pharmacokinetics, Pharmacology, Pharmaceutics, Biochemistry, or related field with 6 years or more of extensive training in the field of drug metabolism and disposition or clinical pharmacology.

Responsibilities

• Deliver scientifically integrated data packages to guide compound selection, study design, portfolio decisions, and regulatory submissions.
• Collaborate with Discovery and Development teams to assess drugability and optimize ADME properties for clinic; design and support nonclinical and clinical studies.
• Lead R&D initiatives to grow ADME/DMPK capabilities across modalities including small molecules, biologics, peptides, ADCs, siRNAs, gene therapies.
• Integrate in vitro, in vivo, and in silico ADME data with biology/chemistry insights to define structure–activity/property relationships.
• Prepare data packages and regulatory content (IB, IND, IMPD, NDA/BLA) to support global submissions and regulator discussions.
• Mentor junior and senior scientists in multi-property optimization using mechanistic ADME principles.
• Communicate the value of mechanistic ADME approaches internally and with regulators.
• Build an external network to stay updated with emerging literature and science.

Skills

ADME science

Pharmacokinetics

Cross-functional collaboration

Regulatory documentation

Data interpretation

Education

Ph.D. in Pharmacokinetics/Pharmacology/Pharmaceutics or related field

Tools

SimCYP

GastroPlus

NONMEM

MATLAB

Job description

Lilly is seeking an experienced pharmaceutical scientist to lead ADME science across diverse modalities, including small molecules and biologics. The role involves guiding experimental design, data interpretation, and cross-functional collaboration to advance candidates toward global submissions.

The position requires a Ph.D. with 6+ years of ADME/drug metabolism expertise, strong communication, and the ability to manage multiple projects while partnering with discovery, toxicology, and