Director, ADME/DMPK: PK/Regulatory Leadership

100 Eli Lilly and Company; Indianapolis (IN); On-site; USD 177,000 - 308,000; Full time

Benefits offered by this job

401(k) plan

Pension

Medical, dental, vision benefits

Well-being programs

Job summary

Lilly is seeking an experienced pharmaceutical scientist to lead ADME science and advance portfolio strategies. You will guide cross-functional teams, design experiments, and interpret data to optimize absorption, distribution, metabolism, and excretion for diverse modalities.

The role emphasizes regulatory-driven data packages, collaboration with Discovery and Development, and rigorous scientific leadership across projects. A Ph.D. and extensive ADME experience are required.

Qualifications

• Ph.D. with 6+ years in drug metabolism and disposition or clinical pharmacology.
• Deep experience in ADME across drug modalities including small molecules and biologics.
• Strong PK/PD knowledge and ability to communicate complex concepts clearly.

Responsibilities

• Deliver scientifically integrated data packages to guide compound selection and regulatory submissions.
• Lead cross-functional teams to assess drugability and optimize ADME properties.
• Develop content for regulatory documents (IB, IND, IMPD, NDA/BLA).
• Mentor junior scientists in multi-property optimization using mechanistic ADME.

Skills

ADME

Pharmacokinetics

Cross-functional

Regulatory communication

Project management

Education

Ph.D. in Pharmacokinetics/Pharmacology/Pharmaceutics/Biochemistry or related

Tools

SimCYP

GastroPlus

NONMEM

Matlab

Job description

Lilly is seeking an experienced pharmaceutical scientist to lead ADME science and advance portfolio strategies. You will guide cross-functional teams, design experiments, and interpret data to optimize absorption, distribution, metabolism, and excretion for diverse modalities.

The role emphasizes regulatory-driven data packages, collaboration with Discovery and Development, and rigorous scientific leadership across projects. A Ph.D. and extensive ADME experience are required.