Director, ADME Innovation & Portfolio Leadership

Eli Lilly and Company; Indianapolis (IN); On-site; USD 177,000 - 308,000; Full time

Benefits offered by this job

Company bonus

Comprehensive benefits

Job summary

Lilly is seeking an experienced pharmaceutical scientist to lead ADME science across cross-functional teams, applying in vitro, in vivo, and in silico approaches to drug disposition for small molecules, biologics, peptides, ADCs, and gene therapies.

The role focuses on experimental design, data interpretation, and delivering data packages to enable portfolio decisions and regulatory submissions, with opportunities to mentor scientists and shape ADME strategy across modalities.

Qualifications

• Ph.D. degree in Pharmacokinetics, Pharmacology, Pharmaceutics, Biochemistry, or related field with 6+ years of training in drug metabolism and disposition or clinical pharmacology.

Responsibilities

• Deliver scientifically integrated data packages to guide compound selection and regulatory submissions.
• Partner with Discovery and Development teams to optimize ADME properties and support nonclinical/clinical studies.
• Lead R&D initiatives to grow ADME/DMPK capabilities across modalities (small molecules, biologics, peptides, ADCs, siRNAs, gene therapies).
• Integrate in vitro, in vivo, and in silico ADME data with biology/chemistry to define SAR/SPR and guide design.
• Prepare data packages for regulatory documents (IB, IND, IMPD, NDA/BLA) and regulatory discussions.
• Mentor junior scientists in multi-property optimization using mechanistic ADME principles.
• Communicate ADME value internally and to regulators; build external networks.

Skills

ADME knowledge

Pharmacokinetics

Cross-functional collaboration

Modeling software

Communication skills

Project management

Drug discovery experience

Education

Ph.D. in Pharmacokinetics/Pharmacology/Pharmaceutics/Biochemistry

Tools

SimCYP

GastroPlus

NONMEM

Matlab

Job description

Lilly is seeking an experienced pharmaceutical scientist to lead ADME science across cross-functional teams, applying in vitro, in vivo, and in silico approaches to drug disposition for small molecules, biologics, peptides, ADCs, and gene therapies.

The role focuses on experimental design, data interpretation, and delivering data packages to enable portfolio decisions and regulatory submissions, with opportunities to mentor scientists and shape ADME strategy across modalities.