Director, HEOR — Value & Real-World Evidence Strategy

centessapharmaceuticalsinc; Boston (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

Centessa Pharmaceuticals in Boston seeks a Director, Health Economics and Outcomes Research (HEOR) to lead strategy and execution across the hypersomnia portfolio. You will shape evidence generation to support regulatory requirements, HTA dossiers, and payer negotiations.

Reporting to the Executive Director, HEOR, you will partner with Medical Affairs, Clinical Development, Market Access, and other functions to translate strategic goals into accountable research plans through the product

Qualifications

• Advanced degree (PhD, PharmD, or Master's) in health economics and outcomes research or related field.
• 10+ years of relevant experience in health economics, outcomes research, epidemiology, or related disciplines.

Responsibilities

• Lead the development of comprehensive HEOR strategies and operational plans for the assigned asset, establishing an early value proposition and sustaining value demonstration.
• Identify and address unmet medical needs, access barriers, and value gaps in collaboration with cross-functional teams to inform evidence and value narratives.
• Collaborate with cross-functional stakeholders to identify evidence needs and translate strategic objectives into actionable, accountable research plans.
• Design and incorporate PRO strategies into clinical development plans and support early market access planning.
• Maintain current knowledge of the regulatory, payer landscape relevant to PRO use, and assess implications for evidence generation.
• Lead and manage HEOR studies, including retrospective and prospective observational studies, database analyses (claims, EHR, registries), and external control arms.
• Support the development of health economic models, AMCP dossiers, value communication materials, and literature reviews to support launch readiness and ongoing value demonstration.
• Ensure all research initiatives adhere to internal study governance and scientific/ethical standards, including securing necessary approvals.
• Manage external vendors, CROs, and research partners to ensure high-quality, on-time study execution and appropriate budget management.
• Measure and track the impact of generated evidence, translating research outputs into practical tools with teams.

Job description

Centessa Pharmaceuticals in Boston seeks a Director, Health Economics and Outcomes Research (HEOR) to lead strategy and execution across the hypersomnia portfolio. You will shape evidence generation to support regulatory requirements, HTA dossiers, and payer negotiations.

Reporting to the Executive Director, HEOR, you will partner with Medical Affairs, Clinical Development, Market Access, and other functions to translate strategic goals into accountable research plans through the product