Director: Biopharmaceutics Predictive Modeling for Oral Drugs

Takeda Pharmaceutical Co.; Boston (MA); On-site; USD 177,000 - 278,000; Full time

Job summary

Takeda Pharmaceutical Co. seeks a senior leader to direct biopharmaceutics predictive modeling for oral drug products. You will build and lead a cross-functional team that integrates mechanistic modeling with experimental data to drive formulation strategies and clinical decisions.

The role requires expertise in PBPK/PBBM, regulatory science, and lifelong development of modeling capabilities within a global organization.

Qualifications

• PhD in Pharmaceutics, Pharmaceutical Sciences, Biopharmaceutics or related field with extensive industry experience.
• Expertise in PBPK/PBBM and mechanistic oral absorption modeling for formulation development.
• Strong track record in developing mechanistic models to inform clinical studies and regulatory decisions.
• Experience integrating modeling results into regulatory submissions and health authority interactions.

Responsibilities

• Provide strategic and operational leadership for biopharmaceutics predictive modeling.
• Lead a high-performing team across Oral Drug Product to integrate modeling with development strategies.
• Direct implementation of PBPK, PBBM, and dissolution–absorption modeling to predict product performance.
• Guide formulation selection, dose optimization, and clinical development decisions across lifecycle.
• Collaborate with CMC, regulatory, analytical sciences, and clinical pharmacology to align plans.

Skills

PBPK/PBBM modeling

Mechanistic biopharmaceutics

Oral drug product development

Regulatory submissions support

Education

PhD in Pharmaceutics or related

Job description

Takeda Pharmaceutical Co. seeks a senior leader to direct biopharmaceutics predictive modeling for oral drug products. You will build and lead a cross-functional team that integrates mechanistic modeling with experimental data to drive formulation strategies and clinical decisions.

The role requires expertise in PBPK/PBBM, regulatory science, and lifelong development of modeling capabilities within a global organization.