Computational Protein Engineer

Job Juncture; Rockville (MD); On-site; USD 120,000 - 180,000; Full time

Job summary

Job Juncture is seeking a Senior Scientist, Protein Engineering to lead hands-on experimental programs and leverage computational tools to accelerate design cycles.

You will lead antibody and protein engineering efforts, drive expression, purification, and characterization, and design binding and functional assays.

Collaborations with structural biologists and computer scientists, plus managing CRO partnerships, will be key to delivering innovative biologics.

Qualifications

• PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience
• Hands-on expertise in protein expression, purification, and characterization
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
• Peer-reviewed publications and/or patents in antibody or protein engineering
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
• Proven ability to lead technical teams and manage complex, multi-faceted projects
• Outstanding written and verbal communication skills

Responsibilities

• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
• Drive protein expression, purification, and characterization workflows across multiple formats
• Design and execute binding and functional assays to evaluate and iterate on engineered proteins
• Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
• Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies
• Manage CRO partnerships including experimental design, vendor communication, and internal reporting

Skills

Protein expression

Protein purification

Protein characterization

Antibody engineering

Bispecifics

Nanobodies

AlphaFold

Rosetta

ProteinMPNN

Team leadership

Communication skills

Education

PhD in biochemistry or related field

Tools

AlphaFold

Rosetta

ProteinMPNN

Job description

Our client is a leading biotech firm advancing innovative antibody and protein engineering programs.

They seek a Senior Scientist, Protein Engineering to lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.

The ideal candidate will take on the following responsibilities:

• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
• Drive protein expression, purification, and characterization workflows across multiple formats
• Design and execute binding and functional assays to evaluate and iterate on engineered proteins
• Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
• Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies
• Manage CRO partnerships including experimental design, vendor communication, and internal reporting

The ideal candidate will possess the following qualifications:

• PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience
• Hands-on expertise in protein expression, purification, and characterization
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
• Peer-reviewed publications and/or patents in antibody or protein engineering
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
• Proven ability to lead technical teams and manage complex, multi-faceted projects
• Outstanding written and verbal communication skills