Computational Protein Engineer

H. T. PROF Group; Rockville, Northern (MD, KY); Hybrid; USD 140,000 - 210,000; Full time

Job summary

H. T. PROF Group in Rockville, MD seeks a computational protein engineer to lead hands-on antibody and protein engineering programs, blending experimental design with computational insights to accelerate design cycles.

You will collaborate with structural biologists and computational scientists, apply AlphaFold and Rosetta to strategy, and guide a multidisciplinary team toward robust, scalable protein therapeutics.

Qualifications

• PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience.
• Hands-on expertise in protein expression, purification, and characterization.
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities.
• Peer-reviewed publications and/or patents in antibody or protein engineering.
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus.

Responsibilities

• Lead experimental design and execution of antibody and protein engineering programs, including affinity maturation and de novo binder design.
• Drive protein expression, purification, and characterization workflows across multiple formats.
• Design and execute binding and functional assays to evaluate engineered proteins.
• Collaborate with structural biologists and computational scientists to integrate structural insights into experiments.
• Apply computational tools such as AlphaFold and Rosetta to support wet lab strategies.

Skills

Protein engineering

Antibody engineering

Computational design

Team leadership

Scientific communication

Education

PhD in biochemistry or related

Tools

AlphaFold

Rosetta

ProteinMPNN

Job description

Do you value scientific rigor, long-term relationships, and working alongside the best in the field?

My client offers scientists genuine latitude to pursue creative endeavors and true research.

My client seeks a Computational Protein Engineer to build and lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.

The ideal candidate will take on the following responsibilities:

• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
• Drive protein expression, purification, and characterization workflows across multiple formats
• Design and execute binding and functional assays to evaluate and iterate on engineered proteins
• Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
• Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies

The ideal candidate will possess the following qualifications:

• PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience
• Hands-on expertise in protein expression, purification, and characterization
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
• Peer-reviewed publications and/or patents in antibody or protein engineering
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
• Proven ability to lead technical teams and manage complex, multi-faceted projects
• Outstanding written and verbal communication skills