Computational Protein Engineer

Keystone Distinction Group; Rockville, Northern (MD, KY); Hybrid; USD 150,000 - 210,000; Full time

Job summary

Keystone Distinction Group is seeking a Computational Protein Engineer to lead hands-on programs in antibody and protein engineering. You will design experiments, execute protein expression and purification workflows, and assess binding and function across multiple formats.

Collaboration with structural biologists and computational scientists will be key to integrating insights into experimental plans. The role requires a PhD with 2+ years in industry, strong publication/patent track record, and

Qualifications

• PhD plus 2+ years of industry experience
• Hands-on expertise in protein expression, purification, and characterization
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
• Peer-reviewed publications and/or patents in antibody or protein engineering
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
• Proven ability to lead technical teams and manage complex, multi-faceted projects
• Outstanding written and verbal communication skills

Responsibilities

• Lead experimental design and execution of antibody and protein engineering programs
• Drive protein expression, purification, and characterization workflows across multiple formats
• Design and execute binding and functional assays
• Collaborate with structural biologists and computational scientists to integrate structural insights
• Apply computational tools such as AlphaFold and Rosetta to support wet lab strategies

Skills

Protein expression

Team leadership

Written & verbal communication

Antibody engineering formats

Computational design tools familiarity

Education

PhD in biochemistry, molecular biology, protein biochemistry, or related discipline

Tools

AlphaFold

Rosetta

ProteinMPNN

Job description

Do you value scientific rigor, long-term relationships, and working alongside the best in the field?

My client offers scientists genuine latitude to pursue creative endeavors and true research.

My client seeks a Computational Protein Engineer to build and lead hands‑on experimental programs while leveraging computational tools to accelerate and inform design cycles.

The ideal candidate will take on the following responsibilities:

• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi‑specific antibody development, and de novo binder design
• Drive protein expression, purification, and characterization workflows across multiple formats
• Design and execute binding and functional assays to evaluate and iterate on engineered proteins
• Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
• Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies

The ideal candidate will possess the following qualifications:

• PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience
• Hands‑on expertise in protein expression, purification, and characterization
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
• Peer‑reviewed publications and/or patents in antibody or protein engineering
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
• Proven ability to lead technical teams and manage complex, multi‑faceted projects
• Outstanding written and verbal communication skills