Computational Protein Engineer

Zaddy Solutions; Rockville (MD); On-site; USD 120,000 - 190,000; Full time

Job summary

Zaddy Solutions in Rockville, MD seeks a Computational Protein Engineer to build and lead hands-on experimental programs while leveraging computational tools to accelerate design cycles. You will work with a world-class team in a fast-paced research environment.

The ideal candidate will drive antibody and protein engineering projects, mentor scientists, and apply AlphaFold/Rosetta to guide wet lab strategies. This role emphasizes collaboration with structural biologists and computational experts.

Qualifications

• PhD in biochemistry or related field with 2+ years industry experience.
• Hands-on experience in protein expression, purification and characterization.
• Experience with antibody engineering formats (bispecifics, nanobodies).
• Peer‑reviewed publications and/or patents in antibody/protein engineering.
• Familiarity with AlphaFold, Rosetta or ProteinMPNN is a plus.
• Proven ability to lead technical teams and manage complex projects.
• Strong written and verbal communication skills.

Responsibilities

• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation and de novo binder design.
• Drive protein expression, purification, and characterization workflows across multiple formats.
• Design and execute binding and functional assays to evaluate engineered proteins.
• Collaborate with structural biologists and computational scientists to integrate structural insights.
• Apply computational tools such as AlphaFold and Rosetta to support wet lab strategies.

Skills

Antibody engineering

Protein expression

Leadership

Publications/patents

Computational design tools

Education

PhD in Biochemistry/Molecular Biology

Tools

AlphaFold

Rosetta

ProteinMPNN

Job description

Do you value scientific rigor, long-term relationships, and working alongside the best in the field?

My client offers scientists genuine latitude to pursue creative endeavors and true research.

My client seeks a Computational Protein Engineerto build and lead hands‑on experimental programs while leveraging computational tools to accelerate and inform design cycles.

The ideal candidate will take on the following responsibilities:

• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi‑specific antibody development, and de novo binder design
• Drive protein expression, purification, and characterization workflows across multiple formats
• Design and execute binding and functional assays to evaluate and iterate on engineered proteins
• Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
• Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies

The ideal candidate will possess the following qualifications:

• PhD in biochemistry, molecular biology, protein biochemistry, or related discipline plus 2+ years of industry experience
• Hands‑on expertise in protein expression, purification, and characterization
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities
• Peer‑reviewed publications and/or patents in antibody or protein engineering
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus
• Proven ability to lead technical teams and manage complex, multi‑faced projects
• Outstanding written and verbal communication skills