Clinical Research Site Manager - Expanding Operations

ACRC Trials; Plano (TX); On-site; USD 90,000 - 150,000; Full time

Job summary

ACRC Trials, headquartered in Plano, TX, is seeking an experienced Clinical Research Site Manager to oversee daily operations across one or more research sites in the Dallas area and beyond. You will drive protocol compliance, operational efficiency, and high-quality study execution while leading site teams, supporting patient recruitment, and coordinating with physicians, sponsors, and CROs.

On-site in Plano with travel to other sites as needed.

Qualifications

• Experience managing two or more clinical research sites.
• Strong experience in clinical trials, protocol execution, and clinical operations.
• Proven project management and leadership skills.
• Excellent organizational, communication, and problem-solving abilities.
• Ability to work effectively in a fast-paced, multi-site environment.
• Experience in clinical research or healthcare required.
• Bachelor’s degree required; advanced degree preferred.

Responsibilities

• Oversee day-to-day clinical trial operations at assigned site(s).
• Ensure compliance with study protocols, GCP, FDA, and IRB requirements.
• Manage site staff, including CRCs, research assistants, and support teams.
• Coordinate with physicians, nurses, sponsors, and CROs.
• Drive patient recruitment, enrollment, and retention strategies.
• Maintain accurate and timely source documentation and data integrity.
• Monitor study timelines, milestones, and performance metrics.
• Prepare for and support monitoring visits, audits, and inspections.
• Identify and resolve operational challenges to ensure study success.

Skills

Leadership

Project management

Organizational skills

Communication

Problem-solving

Multi-site coordination

Fast-paced environment

Education

Bachelor’s degree

Advanced degree preferred

Job description

ACRC TRIALS, headquartered in Plano, TX with multiple locations across North Texas, is a premier clinical research site network working with award-winning physicians, including D Magazine “Best Doctors.”

We are committed to delivering high-quality patient care while advancing medicine through pharmaceutical-sponsored clinical trials. Our team is known for operational excellence, strong enrollment performance, and maintaining the highest standards of ethics, safety, and data integrity.

Role Overview

We are seeking an experienced Clinical Research Site Manager to oversee daily operations across one or more research sites.

This role is responsible for ensuring protocol compliance, operational efficiency, and high-quality study execution, while leading site teams and supporting patient recruitment and retention efforts.

On Site in Plano, TX but able to travel to all sites in the DFW area and Austin, as necessary.

KEY RESPONSIBILITIES

• Oversee day-to-day clinical trial operations at assigned site(s)
• Ensure compliance with study protocols, GCP, FDA, and IRB requirements
• Manage site staff, including CRCs, research assistants, and support teams
• Coordinate with physicians, nurses, sponsors, and CROs
• Drive patient recruitment, enrollment, and retention strategies
• Maintain accurate and timely source documentation and data integrity
• Monitor study timelines, milestones, and performance metrics
• Prepare for and support monitoring visits, audits, and inspections
• Identify and resolve operational challenges to ensure study success

QUALIFICATIONS

• Prior experience managing 2 or more clinical research sites required
• Strong experience in clinical trials, protocol execution, and clinical operations
• Proven project management and leadership skills
• Excellent organizational, communication, and problem-solving abilities
• Ability to work effectively in a fast-paced, multi‑site environment
• Experience in clinical research or healthcare required
• Bachelor’s degree required; advanced degree preferred

Applicants must be authorized to work in the United States for any employer. We are not able to sponsor employment visas at this time.